Defining the membrane protein cargo transported by Retromer

定义由 Retromer 运输的膜蛋白货物

• 批准号: DP160101573
• 负责人: A/Prof Rohan Teasdale
• 金额: $ 32.88万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160101573
• 关键词: Defining; membrane; protein; cargo; transported

This project aims to define the role of Retromer, a protein machine that directs the organisation and movement of proteins within the cell. The function of proteins is dependent on how they travel through the various regions or compartments within the cell. One intracellular compartment, termed endosomes, is central to this dynamic process. Intracellular transport of biomolecules through the endosomal organelle is critical for normal cellular processes such as signalling and development. Endosomal transport occurs within membrane domains and membrane vesicular carriers formed by Retromer. This project aims to define the transmembrane proteins sorted by the distinct retromer complexes that form within the cell and the sorting signals essential for their correct trafficking and localisation.

该项目旨在定义Retromer的作用，Retromer是一种蛋白质机器，指导细胞内蛋白质的组织和运动。蛋白质的功能取决于它们如何穿过细胞内的各个区域或隔室。一个称为内体的细胞内隔室是这一动态过程的核心。生物分子通过内体细胞器的细胞内转运对于正常的细胞过程如信号传导和发育是至关重要的。内体转运发生在由Retromer形成的膜结构域和膜囊泡载体内。该项目旨在定义由细胞内形成的不同逆转录复合物分选的跨膜蛋白，以及对其正确运输和定位至关重要的分选信号。