EFFECT OF GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR(GM-CSF)ON RAT EXPERIMENTAL PERIODONTITIS

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Periodontal diseases are infectious diseases with a bacterial etiology and periodontitis is characterized by a dense infiltration of inflammatory cells: polymorphonuclear leakocytes(PMNs),monocytes,and lymphocytes.Among these cells, PMNs constitute a first line against all forms of injury and microbial challenge around teeth as well as the body.Recently,Hammond et al.reported(N Eng.J.Med.,320, 1306,1989)that recombinat human granulocyte colony-stimulating factor(G-CSF) increased neutrophile turnover almost four-fold without affecting the migrative activity in patients with cyclic neuropenia resulting in reducing the frequency of oropharyngeal inflammation,fever,infections,and recurrent gingivitis.In this study,we examined the effect of recombinat mouse GM-CSF on the oncet and development of experimental gingival hyperplasia or periodontitis in rats or mice. Addition of GM-CSF for 2 weeks to rats or mice resulted in an increase in the number of neutrophiles in mise,but did not in rats.However,the addition of GM-CSF did not affect either the experimental gingilval hyperplasia induced by nifedipine or experimental periodontitis in either animals.