A Neurophysiological Study of Seasonal Affective Disorder-with Special Reference to Changes in the Plasma Level of Tryptophan-

季节性情感障碍的神经生理学研究 - 特别参考血浆色氨酸水平的变化 -

• 批准号: 02670525
• 负责人: NAKAYAMA Kazuhiko
• 金额: $ 1.54万
• 依托单位: Department of Psychiatry, The Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670525/
• 关键词: Phototherapy; Free-Tryptophan; Melatonin; Diurnal Rhythin in Body; Temepature; 月経関連症候群

The author treated 10 patients with seasonal affective disorder (SAD) in the study period 3 years.Although it was in an extremely limited number of SAD patients that phototherapy could be applied in complete compliance with the conditions of the study program, the following notable characteristics of SAD were extracted from them in this study.(1) Characteristics of Biological Traits of SAD and Effects of Phototherapy1) The plasma level of free tryptophan was significantly depressed in the SAD patients,to about 5% of the average value for healthy persons. When the patients were instituted on phototherapy, there was a significant increase of 10% in the plasma level of free tryptophan with the improvement of clinical symptoms.2) The diurnal rhythm of melatonin was not remarkable, but its secretion tended to decrease.3) Cortisol secretion tended to increase all the time, and the reverse was the case with prolactin secretion. With phototherapy, the phase of secretion of melatonin, prolactin,and cortisol was advanced 2 to 3 hours.4) The body temperature rhythm was also advanced about 4 hours, but it cannot necessarily be argued that this effect represents the core of the mechanism of phototherapy.(2) Effects of Phototherapy on the Sexual GlandIt is said that SAD is characteristically common in women, especially those who present with premenstrual tension syndrome. It was suggested that light irradiation, which fails to receive much attention in Japan, was inhibitive of ovulation and luteal function.(3) Relationship of SAD to HeredityWhen this series of SAD patients was examined for familial onset, 3 pairs of a parent and a child were found among the 10 SAD patients. This finding suggests such a strong predisposition to SAD that further studies are warranted in this respect.

作者在3年的研究期间治疗了10例季节性情感障碍（SAD）患者，虽然在极少数SAD患者中，光疗可以完全符合研究计划的条件，但本研究从中提取了SAD的以下显著特征。(1)SAD的生物学特性及光疗的疗效1）SAD患者血浆游离色氨酸水平明显降低，仅为健康人平均水平的5%左右。光疗后，随着临床症状的改善，血浆游离色氨酸水平显著升高10%; 2）褪黑激素的昼夜节律不明显，但其分泌有下降趋势; 3）皮质醇的分泌一直呈增加趋势，而催乳素的分泌则相反。光疗时，褪黑激素、催乳素和皮质醇的分泌期提前2 ~ 3小时。4）体温节律也提前了约4小时，但不能说这种效应代表了光疗机制的核心。(2)光疗对性腺的影响据说SAD在女性中很常见，尤其是那些患有经前紧张综合征的女性。有人认为，光照射，这在日本没有得到太多的关注，是抑制排卵和黄体功能。(3)SAD与遗传的关系对这一系列SAD患者进行家族发病检查时，发现10例SAD患者中有3对父母和一个孩子。这一发现表明SAD的易感性如此之强，在这方面需要进一步的研究。

项目成果

Nakayama,K.: "A Function of Hypothda mus-Pituitary System and Alernotion in the Plasma Level of Free Tryptophan on a Case of Seasonal Afpective Diseroler" The Japanese Jarnal of Psychiatry and Neuvology. 44. 762- (1990)

Nakayama,K.：“季节性情感失调病例中垂体垂体系统的功能和血浆游离色氨酸水平的警报”《日本精神病学和神经病学杂志》。

Nakayama K: "A Function of Hypothalamus-Pituitary System and Alernation in the Plasma Level of Free Tryptophan one a Case of Seasonal Affective Disorder" The Japanese Journal of Psychiatry and Neurology. 44. 762 (1990)

Nakayama K：“下丘脑-垂体系统的功能和游离色氨酸血浆水平的变化一例季节性情感障碍”《日本精神病学和神经病学杂志》。

中山 和彦: "季節性感情障害者の脳内セロトニン活性に関する検討-経過中の血漿中トリプトファン濃度の変動から" 薬物・精神・行動. 10. 523- (1990)

Kazuhiko Nakayama：“季节性情感障碍患者大脑血清素活性的研究 - 来自血浆色氨酸浓度随时间的变化”《药物、精神病学和行为》10. 523- (1990)。

Nakayama K: "Effects of Phototherapy on the Menstrual Cycle" The Japanese Journal of Psychiatry and Neurology. 45. 724 (1991)

Nakayama K：“光疗对月经周期的影响”《日本精神病学和神经病学杂志》。

中山 和彦: "季節性感情障害の一例における神経生物学的検討" 精神医学. 33. 175-184 (1991)

Kazuhiko Nakayama：“季节性情感障碍病例的神经生物学检查”精神病学 33. 175-184 (1991)