The investigation of peptidase inhibition toward diabetic nephropathy and cardiomyopathy

肽酶抑制治疗糖尿病肾病和心肌病的研究

• 批准号: 24790098
• 负责人: NAKAYAMA Kazuhiko
• 金额: $ 2.91万
• 依托单位: Kobe Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790098/
• 关键词: エンドセリン変換酵素; 糖尿病性腎症; 糖尿病性心筋症; 糖尿病心筋症; ブラジキニン; 心房性ナトリウム利尿ペプチド; アドレノメデュリン

We investigated the novel therapeutic mechanism of endothelin converting enzyme (ECE) inhibition toward diabetic concomitant diseases like nephropathy, cardiomyopathy, and limb ischemia by using genetically modified mice. Although ECE was known as synthetic enzyme for endothelin-1, this time, we proved the the potentiating vasodilative peptide as bradykinin, and also anti-inflammatory peptide as calcitonin gene related peptide by inhibiting their degradation. This study is the first investigation to confirm the new mechanism of ECE inhibition in diabetic complication.

我们使用转基因小鼠研究了内皮素转换酶（ECE）抑制剂对糖尿病并发症如肾病、心肌病和肢体缺血的新治疗机制。虽然ECE被认为是内皮素-1的合成酶，但这次我们证明了血管舒张肽的增强作用是缓激肽，抗炎肽是降钙素基因相关肽，通过抑制它们的降解。本研究首次证实了ECE抑制在糖尿病并发症中的新机制。

项目成果

The therapeutic potential targeting endothelin converting enzyme towards pulmonary hypertension and fibrosis.

针对肺动脉高压和纤维化的内皮素转化酶的治疗潜力。

• 发表时间: 2013
• 作者: Kazuhiko Nakayama;Anggoro Budi Hartopo;Budhi Raharjo Sunu;Yoko Suzuki; Noriaki Emoto;Ken-ichi Hirata
• 通讯作者: Ken-ichi Hirata

神戸薬科大学 臨床薬学研究室

神户药科大学临床药学实验室

Endothelin-Converting Enzyme-1 in Pulmonary Hypertension

内皮素转换酶 1 在肺动脉高压中的作用

• 发表时间: 2013
• 作者: Sunu B. Raharjo;Noriaki Emoto;Yoga Yuniadi;Kazuhiko Nakayama;Ganesja M. Harimurti
• 通讯作者: Ganesja M. Harimurti

ET-1 from endothelial cells is required for complete angiotensin II-induced cardiac fibrosis and hypertrophy

• DOI: 10.1016/j.lfs.2012.02.006
• 发表时间: 2012-10-15
• 期刊: LIFE SCIENCES
• 影响因子: 6.1
• 作者: Adiarto, Suko;Heiden, Susi;Emoto, Noriaki
• 通讯作者: Emoto, Noriaki

Noninvasive and Simple Assessment of Cardiac Output and Pulmonary Vascular Resistance With Whole-Body Impedance Cardiography Is Useful for Monitoring Patients With Pulmonary Hypertension

• DOI: 10.1253/circj.cj-13-0172
• 发表时间: 2013-09-01
• 期刊: CIRCULATION JOURNAL
• 影响因子: 3.3
• 作者: Taniguchi, Yu;Emoto, Noriaki;Hirata, Ken-ichi
• 通讯作者: Hirata, Ken-ichi