The immune functions in aged cynomolgus monkeys as an experimental model.

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According to the increase in population of aged people, the immune status of aged humans is demanded to be studied to prevent them from disease's. We have been studied the immune system in aged cynomolgus monkeys to establish a model for clarifying the age-related change of immune functions in humans. The results obtained in 2 years were as follows and the cymonolgus monkey were considered to be very useful model to study the effect of aging.1)Since CH50 value and anti-A and anti-B activity levels reached the peak at 5 to 10 years of age and declined, the monkeys older than 20 years old are considered as aged monkeys.2)The subset labels of pant CD4+, CD8+ cells in cynomolgus monkeys increased according to aging although the ones of B and NK cells decreased.3)Interestingly relative high percentage of CD4+/CD8+ cells are observed in monkey peripheral blood in contrast to human and it increased with aging which suggest that the cynomolgus monkey is useful model to study the age-associated decline in thymus function and the differential mechanism of T cells.4)Comparing with young monkeys, autoantibodies are higher and T cell functions especially the productivity of IL-2 and the activity of IL-2R expression were considerably lower in aged monkeys. The NK activity and the phagocytic activity of macrophages were not changed with aging.5)Antibodies to recognize monkey B cells were obtained in anti-human B cells monoclonal and polyclonal antibodies.6)The assay system to study monkey B cell blastogenic activity was established.