Analysis of factors implicated in pathogenicity of mononegaviruses and development of a vaccine candidate.

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We investigated the key factors in pathogenicity of morbilliviruses, and developed a vaccine for Nipah virus infection. For morbilliviruses, it was discovered that MV induced different cellular responses in a cell-type specific mannar, and viral nucleocapsid protein had inhibitory potency for IFN-α/β and γ signaling. For Nipah virus, we showed that accessory proteins play key roles in it's pathogenicity. We have also showed that our established recombinant measles virus expressing Nipah virus protein effectively protected hamsters from NiV infection.