Immuno-pathological studies in IgA nephropathy : The role of virus for etiological and progressive factors
Immuno-pathological studies in IgA nephropathy : The role of virus for etiological and progressive factors
批准号:
03670502
负责人:
SUZUKI Hitoshi
金额:
$1.34万
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1991
资助国家:
日本
项目状态:
已结题
起止时间:
1991 至 1993
中文摘要
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英文摘要
In order to a movement of virus in an experimental model of IgA nephropathy, detecting a virus-specific RNA using an in situ hybridization and a virus-surface protein with an immunoflurorescence study of mice intravenously inculated once with coxsackievirus B4 (10^7TCD_<50> : Cox.B4) were carried out.The signal of the Cox.B4-specific RNA was observed in the mesangial areas from 6 hours to 28 days after the inoculation. Cox.B4-surface protein was not detected at 6 hours after the inoculation, but was observed at 28 days in the mesangial areas.Inoculated Cox.B4 have revealed the signal of the Cox.B4-specific RNA in the mesangial areas for a long time, and produce the surface protein in the same areas after 28 days. These findings suggest that in situ immune complexes are maked by responding to virus-surface protein and virus antibody in the mesangial areas.
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鈴木 仁: "ウイルス(糸球体腎炎)" 腎と透析. 31. 255-259 (1991)
铃木仁:“病毒(肾小球肾炎)”《肾脏与透析》31. 255-259(1991)。
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通讯作者:
Shigeo Mutoh et al.: "Detection of Coxsackie B4 Virus RNA in Infected Mice Kidneys by in situ Hybridization" Nephron.
Shigeo Mutoh 等人:“通过原位杂交检测受感染小鼠肾脏中的柯萨奇 B4 病毒 RNA”肾单位。
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久米 一成: "ウイルス性腎炎の研究(第14報)" 第34回日本腎臓学会総会予稿集. 290 (1991)
Kazunari Kume:“病毒性肾炎的研究(第14次报告)”日本肾病学会第34届年会论文集290(1991)。
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Shigeo Mutoh ed tl.: "Detection of Coxsackie B4 Virus RNA in Infected Mice Kidneys by in situ Hybridization" Nephron.(1994)
Shigeo Mutoh 编辑:“通过原位杂交检测受感染小鼠肾脏中的柯萨奇 B4 病毒 RNA”Nephron。(1994)
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神山 諭: "Coxsackie B_4ウイルスによる実験的腎炎ーウイルスの頻回接種による腎糸球体変化ー" 日本腎臓学会誌. 32. 939-948 (1990)
Satoshi Kamiyama:“柯萨奇 B_4 病毒引起的实验性肾炎 - 频繁接种病毒导致的肾小球变化”日本肾病学会杂志 32. 939-948 (1990)。
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