Clinical Epidemiology of HTLV-I and HTLV-II Infection

描述（由申请人提供）： 在我的学术生涯的中点，我一直在以病人为导向的研究生产，在一些著名的期刊，国家和国际认可的证据，并从美国国立卫生研究院和其他资金来源良好的资助记录的出版物记录。我的流行病学研究实验室对人类逆转录病毒人类T淋巴细胞病毒I型和II型（HTLV-I和-II）的健康结局进行临床流行病学研究，我的NIH R 01资助的多中心HTLV队列研究构成了本申请研究计划的核心。我还研究输血传播病毒的流行病学和献血者的人口统计学和献血行为。我目前的研究环境包括UCSF实验室医学和流行病学与生物统计学部门，我的学术之家，以及太平洋血液中心（BCP），一个社区血库，距离UCSF校园1英里，我的流行病学实验室和密切合作者都在那里。这些机构的负责人的信件支持我的K24申请，并记录了UCSF和BCP之间在研究和培训方面的紧密联系。我已经指导了一些研究生和博士后研究人员，以及一些寻求临床流行病学研究额外培训的专业人士。我在这一点上申请K24补助金，因为我想减少我在临床职责和具体资助项目上的努力，以追求以患者为导向的研究的新兴趣，并扩大我的指导活动。新学员将在HTLV临床结果、输血传播病毒感染或献血者人口统计学和献血行为流行病学的新领域开展监督流行病学研究项目。他们将参加由UCSF流行病学和生物统计学系提供的临床研究课程培训。最后，我将扩展BCP在NIH Fogarty国际中心资助下组织的国际输血安全培训计划。该项目将来自欠发达国家的血库管理员带到一个与血液安全相关的研究方法的强化夏季培训项目中。

DESCRIPTION (provided by applicant): At the mid-point of my academic career, I have been productive in patient-oriented research, as documented by publications in a number of prominent journals, evidence of national and international recognition, and a good funding record from the NIH and other funding sources. My Epidemiology Research Laboratory does clinical epidemiology research in the health outcomes of human retroviruses human T-lymphotropic virus types I and II (HTLV-I and -II), and my NIH R01-funded multicenter HTLV cohort study forms the centerpiece of the Research Plan in this application. I also study the epidemiology of transfusion-transmitted viruses and of blood donor demographics and donation behavior. My current research environment includes both the UCSF Departments of Laboratory Medicine and Epidemiology & Biostatistics, my academic home, and Blood Centers of the Pacific (BCP), a community blood bank 1 mile from the UCSF campus where my Epidemiology Lab and close collaborators are located. Letters from the heads of these institutions support my K24 application, and document the strong affiliations in research and training between UCSF and BCP. I have already mentored a number of graduate students and postdoctoral researchers, as well as several professionals seeking additional training in clinical epidemiology research. I am applying for a K24 grant at this point because I would like to reduce my effort on clinical duties and specific funded projects in order to pursue new interests in patient-oriented research and to expand my mentoring activities. The new trainees would carry out supervised epidemiology research projects in HTLV clinical outcomes, in transfusion transmitted viral infections, or a new area in the epidemiology of blood donor demographics and donation behavior. They will participate in the Training in Clinical Research courses given by the UCSF Department of Epidemiology and Biostatistics. Finally, I shall expand an existing training program in International Transfusion Safety organized by BCP under an NIH Fogarty International Center grant. This program brings blood bankers from less developed countries for an intensive summer training program in research methods related to blood safety.