Clinical Epidemiology of HTLV-I and HTLV-II Infection

HTLV-I 和 HTLV-II 感染的临床流行病学

• 批准号: 6991203
• 负责人: EDWARD L MURPHY
• 金额: $ 13.23万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-05 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6991203
• 关键词: World Health Organization; arthritis; blood bank /supply contamination; blood transfusion; bone marrow disorder; clinical research; communicable disease transmission; epidemiology; human T cell lymphotropic virus type 1; human T cell lymphotropic virus type 2; human subject; outcomes research; patient oriented research; statistics /biometry; training; viral carcinogenesis

DESCRIPTION (provided by applicant): At the mid-point of my academic career, I have been productive in patient-oriented research, as documented by publications in a number of prominent journals, evidence of national and international recognition, and a good funding record from the NIH and other funding sources. My Epidemiology Research Laboratory does clinical epidemiology research in the health outcomes of human retroviruses human T-lymphotropic virus types I and II (HTLV-I and -II), and my NIH R01-funded multicenter HTLV cohort study forms the centerpiece of the Research Plan in this application. I also study the epidemiology of transfusion-transmitted viruses and of blood donor demographics and donation behavior. My current research environment includes both the UCSF Departments of Laboratory Medicine and Epidemiology & Biostatistics, my academic home, and Blood Centers of the Pacific (BCP), a community blood bank 1 mile from the UCSF campus where my Epidemiology Lab and close collaborators are located. Letters from the heads of these institutions support my K24 application, and document the strong affiliations in research and training between UCSF and BCP. I have already mentored a number of graduate students and postdoctoral researchers, as well as several professionals seeking additional training in clinical epidemiology research. I am applying for a K24 grant at this point because I would like to reduce my effort on clinical duties and specific funded projects in order to pursue new interests in patient-oriented research and to expand my mentoring activities. The new trainees would carry out supervised epidemiology research projects in HTLV clinical outcomes, in transfusion transmitted viral infections, or a new area in the epidemiology of blood donor demographics and donation behavior. They will participate in the Training in Clinical Research courses given by the UCSF Department of Epidemiology and Biostatistics. Finally, I shall expand an existing training program in International Transfusion Safety organized by BCP under an NIH Fogarty International Center grant. This program brings blood bankers from less developed countries for an intensive summer training program in research methods related to blood safety.

描述(由申请人提供)： 在我学术生涯的中期，我一直在以患者为中心的研究中卓有成效，许多著名期刊上的出版物、国家和国际认可的证据以及来自NIH和其他资金来源的良好资金记录都证明了这一点。我的流行病学研究实验室对人类逆转录病毒人类T淋巴细胞白血病病毒I型和II型(HTLV-I和-II)的健康后果进行临床流行病学研究，我的NIH R01资助的多中心HTLV队列研究构成了本申请研究计划的核心。我还研究了输血传播病毒的流行病学以及献血者的人口统计学和献血行为。我目前的研究环境包括加州大学旧金山分校的实验室医学系和流行病学与生物统计学系(我的学术总部)，以及太平洋血液中心(BCP)，这是一个社区血库，距离我的流行病学实验室和密切合作伙伴所在的加州大学旧金山分校1英里。这些机构负责人的来信支持我的K24申请，并记录了加州大学旧金山分校和BCP在研究和培训方面的密切联系。我已经指导了一些研究生和博士后研究人员，以及几名寻求临床流行病学研究额外培训的专业人员。在这一点上，我正在申请K24拨款，因为我想减少我在临床职责和特定资助项目上的努力，以便在以患者为导向的研究中追求新的兴趣，并扩大我的指导活动。新学员将在HTLV临床结果、输血传播病毒感染或献血人口统计和献血行为流行病学的新领域开展有监督的流行病学研究项目。他们将参加加州大学旧金山分校流行病学和生物统计学系开设的临床研究课程的培训。最后，我将扩大由BCP在NIH Fogarty国际中心赠款下组织的现有国际输血安全培训计划。该项目吸引了来自欠发达国家的血液银行家参加与血液安全相关的研究方法的夏季强化培训项目。