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An Study of Development of Method for Evaluation of Brain Function Using MEEG.

利用 MEEG 评估脑功能的方法开发研究。

基本信息

批准号：
04557050
负责人：
TORU Michio
金额：
$ 8.9万
依托单位：
Faculty of Medicine, Tokyo Medical and Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04557050/
关键词：
MEEG EEG Dipole-tracing MRI Eplepsy ダイポール高次脳機能

项目摘要

It was aimed to develop the way of the accurate estimation of three-dimensional dipole locations of MEEG and EEG on three-dimensional MRI.An algorithm was developed in which the estimated equivalent dipoles are interposed on the three-dimensional MRI by means of overlapping the head shape measured for a model for dipole tracing and that obtained from the reconstruction of MRI data. For the estimation of dipole locations of EEG.the shape of subject's scalp and the three-dimensional locations of the 21 electrodes used according to the 10-20 system have to be measured with a special device. The dipole tracing method on a one- or two- dipole model with a correction based on a realistic head model were adopted for the estimation od equivalent dipoles of EEG.The estimated equivalent dipoles are located on the three-dimensional MRI by means of overlapping the head shape and that obtained from the three-dimensional MRI.This algorithm is applicable in the estimation of equivalent dipoles of MEEG on precise brain anatomy.An attempt was carried out to use the developed method to estimate ictal EEG associated with epigastric aura which was incidentally observed and recorded in the case of a woman with temporal lobe epilepsy probably due to a hemangioma in the left mesial temporal lobe. The center of the equivalent dipoles during the burst of slow waves was found to be located close to the hemangioma and the lSD of the dipoles was about 10mm. This result suggests that the developed method is valid and useful for the identification of brain function on precise brain anatomy.

为了在三维MRI上准确估计MEEG和EEG的三维偶极子位置，提出了一种将偶极子追踪模型的头形与MRI数据重建得到的头形重叠的方法，将估计的等效偶极子插入三维MRI上。为了估计EEG的偶极子位置，必须用专用设备测量受试者头皮的形状和根据10-20系统使用的21个电极的三维位置。本文采用基于真实头模型校正的单偶极子或双偶极子模型偶极子追踪法估计脑电等效偶极子，并通过头形状与三维磁共振成像（MRI）结果的叠加，在三维MRI上定位脑电等效偶极子。该算法适用于精确脑解剖的MEEG等效偶极子的估计。尝试使用所开发的方法来估计MEEG的等效偶极子。在一名患有颞叶癫痫的女性患者中偶然观察到并记录了与上腹先兆相关的发作性EEG，可能是由于左内侧颞叶血管瘤所致。发现在慢波爆发过程中等效偶极子的中心位于血管瘤附近，偶极子的lSD约为10 mm。这一结果表明，所开发的方法是有效的和有用的识别精确的脑解剖的脑功能。