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Development of a method to estimate diffuse cerebral activities using multi-channel EEGs and 3D-MRI.

开发一种使用多通道 EEG 和 3D-MRI 评估弥漫性大脑活动的方法。

基本信息

批准号：
07557241
负责人：
TORU Michio
金额：
$ 2.05万
依托单位：
Tokyo Medical and Dental University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07557241/
关键词：
Dipole tracing EEG MRI Corticogram MRI

项目摘要

1) Development of a multi-channel EEGs measuring method The methods and devices that digitalize EEGs of 64 channels using a computer were developed. Furthermore, we have developed a special cap that fits many electrods on scalp.2) Development of algorithm that reconstruct 3D-brain structure using digitized 3D-MRI data.Algorithm that extracts the scalp, cranium, cerebrospinal fluid cavity, cerebrum form 3D-MRI and reconstructs a 3D wire frame model was developed.3) EEG analysis on mental disorders1. EEG study on schizophrenic patients : A comparison between neuroleptic-naive state and after treatment was performed.2. Quantitative EEG correlates of normal aging in the elderly were studied.3. Estimation of epileptic source generator using dipole tracing method and 3D-MRI was performed.4. Ethanol-induced alternations in EEG was investigated as a biological marker for alcoholism.4) Development of algorithm that estimates spatially spread cerebral activityWe have developed 'Corticograma', that is a method to estimate the electrical potential of a cerebral surface from the electrical potential on the scalp. Based on this method, a electrical potential distribution of a cerebral surface was estimated based on a potential distribution of the scalp using Scalp-Skull-Cortex Model (SSB Model). The information in Corticogram increases according to the increase in the number of the electrodes attached on the scalp. The validity and error of estimation of Corticogram was evaluated.

1)一种多导脑电测量方法的研制开发了一种用计算机实现64导脑电数字化的方法和装置。2）基于3D-MRI数据的脑三维结构重建算法的开发，从3D-MRI数据中提取头皮、颅骨、脑脊液腔、大脑，并重建三维线框模型。3）精神疾病的脑电分析1.精神分裂症患者的脑电图研究：比较未用抗精神病药状态与治疗后的脑电图变化.研究了老年人正常衰老的定量脑电图相关性.使用偶极追踪法和3D-MRI对癫痫源发生器进行估计。4.研究了乙醇诱导的EEG变化作为酒精中毒的生物标志物。4）估计空间分布的大脑活动的算法的开发我们已经开发了“Corticograma”，这是一种从头皮上的电位估计大脑表面电位的方法。基于该方法，使用头皮-颅骨-皮层模型（SSB模型）基于头皮的电位分布来估计大脑表面的电位分布。皮质描记图中的信息随着附着在头皮上的电极数量的增加而增加。对皮质图估计的有效性和误差进行了评价。