Development of the automated double product break-point determining system

自动化双产品断点确定系统的开发

• 批准号: 06558008
• 负责人: TANAKA Hiroaki
• 金额: $ 6.53万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06558008/
• 关键词: double product; blood lactate thereshold; exercise testing; physical fitness; exercise prescription; 心筋酵素消費量

Catecholamine concentrations are known to sharply increase in the blood at work rates above the blood lactate threshold (LT), and thus we hypothesized that the double product (DP,heart rate-systolic blood pressure product) may also abruptly increase at work rates above the LT.This research was aimed at devising automatic DPBP measurement system and to clarify whether the DPBP could determined during a ramp test on treadmill and cycle ergometer using thsi system. We devised the system which could measure SBP and HR automaticaly and displayd those on the monitor during exercise using a personal computer (NEC PC98). By this modification, we could automatically measure the DP almost every 15 sec. The DPBP was automatically determined using a computer algorithm as follows. The liner regression lines of DP as a function of W were calculated for all possible divisions of the data into two adjustment groups, and then the break-point was determined by the intersection of the two lines which represented the minimum residual sum of the squares. This modified apparatus could be used to determine DPBP in all suqomects including elderly and cardiac patient with a ramp test on treadmill as well as cycle ergometer. The test-retest reliability to determine the DPBP and correlation among the determined DPBP,LT,and VT was fairly good. Based on the above findings we therefore concluded that DPBP determined by this system is easy and a valid for evaluating a physical fitness and prescribing a optimal intensity.

已知在高于血乳酸阈值（LT）的工作速率下，血液中的儿茶酚胺浓度急剧增加，因此我们假设，（DP，心率-收缩压乘积）本研究旨在设计一套DPBP自动测量系统，并探讨能否在跑步机和踏车上进行斜坡测试时，测定DPBP使用该系统。我们设计了一套能在运动中自动测量收缩压和心率并显示在监护仪上的系统。通过这种修改，我们几乎可以每15秒自动测量DP。DPBP使用如下计算机算法自动确定。对于所有可能将数据划分为两个调整组的情况，计算DP作为W的函数的线性回归线，然后通过代表最小残差平方和的两条线的交点确定断点。该装置可用于老年人和心脏病患者的DPBP测定，并可进行平板运动试验和踏车运动试验。DPBP测定的重测信度及DPBP、LT、VT之间的相关性较好。基于上述发现，我们因此得出结论，由该系统确定的DPBP是简单和有效的评估身体素质和处方的最佳强度。

项目成果

Kazuhiro Masuoka, Kimitaka Sagawa, Manabu Mochizuki, Kotaro Oizumi, Kyogo Itoh: "Polyclonal use of T-cell receptor alpha for human T-cell lymphotropic virus type 1-infected T cells." Investigative Ophthalmology & Visual Science. 36. 254-258 (1995)

Kazuhiro Masuoka、Kimitaka Sakawa、Manabu Mochizuki、Kotaro Oizumi、Kyogo Itoh：“T 细胞受体 α 的多克隆用途用于人类 T 细胞嗜淋巴细胞病毒 1 型感染的 T 细胞。”

Ayako Ono, Manabu Mochizuki, Kazunari Yamaguchi, Norio Miyata, Toshiki Watanabe: "Increased number of circulating HTLV-1 infected cells in peripheral blood mononuclear cells of HTLV-1 uveitis patients : a quantitative polymerase chain reaction study." Bri

Ayako Ono、Manabu Mochizuki、Kazunari Yamaguchi、Norio Miyata、Toshiki Watanabe：“HTLV-1 葡萄膜炎患者外周血单核细胞中循环 HTLV-1 感染细胞数量增加：一项定量聚合酶链反应研究。”

Hiroaki Tanaka, Akira Kiyonaga Yasunori Terao, Kojiro Ide, Miyoko Yamauchi, Mamoru Tanaka, Munehiro Shindo: "The double product response is accelerated above the blood lactate threshold" Medicine & Science in Sports & Exercise. (in press). (1996)

Hiroaki Tanaka、Akira Kiyonaga Yasunori Terao、Kojiro Ide、Miyoko Yamauchi、Mamoru Tanaka、Munehiro Shindo：“双产品反应加速至血乳酸阈值以上”

Kimitaka Sagawa, Manabu Mochizuki, Kazuhiro Masuoka, Kazuko Katagiri, TakafumiKatayama, Tomoyuki Maeda, Akihide Tanimoto, Sunao Sugita, Toshiki Watanabe, Kyogo Itoh: "Immunopathogical mechanisms of human T-cell lymphotropic virus type 1 (HTLV-I) uveitis :

Kimitaka Sakawa、Manabu Mochizuki、Kazuhiro Masuoka、Kazuko Katagiri、TakafumiKatayama、Tomoyuki Maeda、Akihide Tanimoto、Sunao Sugita、Toshiki Watanabe、Kyogo Itoh：“人类 T 细胞嗜淋巴细胞病毒 1 型 (HTLV-I) 葡萄膜炎的免疫病理机制：

Manabu Mochizuki: "Human T-lymphotropic virus type 1 and its ocular manifestations." International Ophthalmology Clinics. 35. 107-120 (1995)

Manabu Mochizuki：“人类 T 淋巴细胞病毒 1 型及其眼部表现。”