The Search for Natural Anticancer Substances in East Africa

在东非寻找天然抗癌物质

• 批准号: 07042011
• 负责人: KATO Atsushi
• 金额: $ 2.62万
• 依托单位: Kobe Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07042011/
• 关键词: Anticancer; Chemoprevention; Antipromotor; African medicines; Uvaria sp.; Maytenus sp.; Natural medicines; Mitogenic activity; Hypoxis sp.

Many naturally occurring anticancer substances have been isolated from plants and marine products, and their chemical modification are tried for further strong effect and safety as medicine in various institutes. A number of these compounds are used clinical medicines.Recently, anticancer substances searched in natural resources are taken seriously not only as a killer of cancer cell but also as preventive activator against carcinogenesis.The substances having potent chemical preventive action against cancer are found in everyday our foods.We intend to search more strong anticancer substances without side effects and inclusive of a chemoprevention in Africa traditional medicines and unused natural resources.In this exploration, we have collected the plants of 15 species (Uvaria sp., Maytenus sp., ... etc.) in Kenya and Madagascar, which will be subjected to screening test for inhibition to various carcinogenesis.

许多天然存在的抗癌物质已经从植物和海产品中分离出来，并且它们的化学修饰在各个研究所中被尝试用于进一步的强效和安全的药物。其中许多化合物被用作临床药物。最近，从自然资源中发现的抗癌物质不仅是癌细胞的杀伤剂，而且也是预防癌发生的活化剂。在我们日常的食物中发现了对癌症具有有效化学预防作用的物质。我们打算在非洲传统药物中寻找更强的抗癌物质，没有副作用，包括化学预防和未利用的自然资源。在这次探索中，我们收集了15种植物（紫玉盘属，美登木属，...等等）。在肯尼亚和马达加斯加，将进行抑制各种致癌作用的筛选试验。

项目成果

ATSUSHI KATO: "Mitogenic Activities in African Traditional Herbal Medicines" Planta Med.59. 354-358 (1993)

ATSUSHI KATO：“非洲传统草药中的促有丝分裂活性”Planta Med.59。

ATSUSHI KATO: "ACYCLIC TRITERPENOIDS FROM EKEBERGIA CAPENSIS" Phytochemistry. (in press). (1996)

加藤厚：“来自 EKEBERGIA CAPENSIS 的无环三萜类化合物”植物化学。

ATSUSHI KATO: "Inhibition by some African Traditional Medicines of the Tumor-Promotion Activity of TPA in Mouse-Skin Carcinogensis" Int.J.Cancer. (in preparation).

ATSUSHI KATO：“一些非洲传统药物对 TPA 在小鼠皮肤致癌作用中的肿瘤促进活性的抑制”Int.J.Cancer。

加藤 篤: "Inhibition by some African Traditional Medicines of the Tumor-Promotion Activity of TPA in Mouse-Skin Carcinogensis" Int.J.Cancer. (予定).

Atsushi Kato：“一些非洲传统药物对小鼠皮肤致癌作用中 TPA 的肿瘤促进活性的抑制”Int.J.Cancer（计划中）。

加藤 篤: "Mitogenic activities in African traditional herbal medicines (Part II)^★" Phytomedicine. 2. 335-339 (1996)

Atsushi Kato：“非洲传统草药的促有丝分裂活性（第二部分）^★”植物医学。2. 335-339 (1996)