Neuroendocrine and immune system in genetically polydipsic mice and development of animal model in response to environmental stress

遗传性多饮小鼠的神经内分泌和免疫系统以及响应环境应激的动物模型的建立

基本信息

项目摘要

The purpose of this study was to investigate the characteristics of genetically polydipsic mice from the higher function to genetics and the mechanisms of the neuroendocrine and immune responses to environmental stress in order to establish the animal model in response to the environmental stress. The polydipsic mice showed multiple abnormality as follows. 1. They may have abnormality of the muscarinic receptors in the saalivary glands and blood vessels. 2. The activity of the superior laryngeal nerve was lowar than control mice and large responses to high concentration of saline. 3. The thereshold of the nociceptive stress was lower tahn control mice and may be involved in the abnormality of mu-opiod receptor. 4. Although the number of thymic cells was increased, the differentiation of T cell was abnormal. 5. The glucocorticoid receptors expressed highly in the hypothalamic paraventricular nucleus, subfornical organ, amygdala and hippocampus. 6. The production of nitric oxide (NO) and NO synthase were increased in the paraventricular nucleus and decreased in the posterior pituitary. 7. The expression of vasopressin gene in the hypothalamus was increased after they became polydipsia. The genes of vasopressin and V2 receptor had no essential mutation. 8. Learning behavior showed abnormal in comparison with control mice. These results suggest that genetically polydipsic mice have multiple abnormality and useful animal model to investigate the responses to environmental stress.
本研究的目的是从高等功能到遗传学等方面探讨遗传性烦渴小鼠的特征以及对环境应激的神经内分泌和免疫反应机制,以建立应对环境应激的动物模型。烦渴小鼠表现出如下多种异常。 1.唾液腺和血管中的毒蕈碱受体可能存在异常。 2、喉上神经活性较对照小鼠低,对高浓度生理盐水反应大。 3.伤害性应激阈值低于对照组小鼠,可能与μ阿片受体异常有关。 4.胸腺细胞数量虽增多,但T细胞分化异常。 5.糖皮质激素受体在下丘脑室旁核、穹窿下器、杏仁核和海马高表达。 6.一氧化氮(NO)和NO合成酶的产生在室旁核中增加,在垂体后叶中减少。 7、多饮后下丘脑加压素基因表达增加。加压素和V2受体基因无本质突变。 8.与对照小鼠相比,学习行为表现出异常。这些结果表明,遗传性烦渴小鼠具有多种异常,是研究对环境应激反应的有用动物模型。

项目成果

期刊论文数量(209)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Oka,T.: "Intracerebroventricular injection of tumor necrosis factor α induces thermal hyperalgesia in rats." Neuroimmunomodulation. 3. 135-140 (1996)
Oka, T.:“脑室内注射肿瘤坏死因子 α 会引起大鼠热痛觉过敏。” 神经免疫调节。 3. 135-140 (1996)
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堀 哲郎: "最新内科学大系、Part I.内科総論部門、第2巻「科学としての内科学」" 中山書店, 372 (1996)
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Nagatomo, T.et al.: "Proadrenomedullin N-terminal 20 peptide (PAMP) reduces inward currents and Ca2_+ rises indeuced by nicotine in bovine adrenal medullary cells." Life Sci.59 (20). 1723-1730 (1996)
Nagatomo, T. 等人:“前肾上腺髓质素 N 末端 20 肽 (PAMP) 减少了牛肾上腺髓质细胞中尼古丁引起的内向电流和 Ca2+ 升高。”
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Kannan, H.et al.: "Effects of systemic intgerleukin-1beta administration on daily drinking and renal excretory function in conscious rats." Physiol. Behav.61. 707-715 (1996)
Kannan, H.等人:“全身性白细胞介素-1β给药对清醒大鼠日常饮酒和肾排泄功能的影响。”
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YAMASHITA Hiroshi其他文献

Numerical study on the extent of flow regulation by collateral circulation of cerebral arteries
脑动脉侧支循环流量调节程度的数值研究
A concept on velocity estimation from magnetic resonance velocity images based on variational optimal boundary control
基于变分最优边界控制的磁共振速度图像速度估计概念
  • DOI:
    10.1299/jbse.22-00050
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    OTANI Tomohiro;YAMASHITA Hiroshi;IWATA Kazuma;ILIK Selin Yavuz;YAMADA Shigeki;WATANABE Yoshiyuki;WADA Shigeo
  • 通讯作者:
    WADA Shigeo

YAMASHITA Hiroshi的其他文献

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{{ truncateString('YAMASHITA Hiroshi', 18)}}的其他基金

Potential new food web route for coral reef ecosystems based on zooxanthellae
基于虫黄藻的珊瑚礁生态系统潜在的新食物网路线
  • 批准号:
    18H02270
  • 财政年份:
    2018
  • 资助金额:
    $ 12.03万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
The relationship between hearing loss and vascular disorders in metabolic syndrome patients
代谢综合征患者听力损失与血管疾病的关系
  • 批准号:
    15K10751
  • 财政年份:
    2015
  • 资助金额:
    $ 12.03万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of Heat Recirculating Type Ultra-micro Combustor with Porous Medium Injector
多孔介质喷射器热循环式超微型燃烧器的研制
  • 批准号:
    25420158
  • 财政年份:
    2013
  • 资助金额:
    $ 12.03万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The relationship between the metabolic syndrome and presbycusis
代谢综合征与老年性耳聋的关系
  • 批准号:
    24592551
  • 财政年份:
    2012
  • 资助金额:
    $ 12.03万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Discharge pattern of symbiotic zooxanthellae from corals
珊瑚共生虫黄藻的排放模式
  • 批准号:
    23770032
  • 财政年份:
    2011
  • 资助金额:
    $ 12.03万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Investigation in the pathogenesis of metabolic syndrome with in vivo molecular imaging
体内分子影像研究代谢综合征发病机制
  • 批准号:
    23591298
  • 财政年份:
    2011
  • 资助金额:
    $ 12.03万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Transformation and Reorganization of Ethnic Religions in the Diaspora with Reference to the dynamism of Hindu and Taoist Ritual Traditions
参考印度教和道教仪式传统的活力,散居海外的民族宗教的转型和重组
  • 批准号:
    22401017
  • 财政年份:
    2010
  • 资助金额:
    $ 12.03万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
DEVELOPMENT OF NUMERICAL ANALYSIS METHOD BASED ON REACTIVE FLUID MECHANICS FOR INVESTIGATION OF COMBUSTION PHENOMENON IN POROUS MEDIUM
基于反应流体力学研究多孔介质燃烧现象的数值分析方法的发展
  • 批准号:
    22560193
  • 财政年份:
    2010
  • 资助金额:
    $ 12.03万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Geometric invariants and model theory for singular unitary representations
奇异酉表示的几何不变量和模型理论
  • 批准号:
    22540002
  • 财政年份:
    2010
  • 资助金额:
    $ 12.03万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Relationship between Aging and Heat Shock Response in the Inner Ear
衰老与内耳热休克反应之间的关系
  • 批准号:
    21592157
  • 财政年份:
    2009
  • 资助金额:
    $ 12.03万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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High resolution genomic and epigenomic mapping of the human salivary gland
人类唾液腺的高分辨率基因组和表观基因组图谱
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