Possible remodeling of the callosal fibers affected by the callosotomy

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Changes in the number of spines on apical dendrites of pyramidal neurons in layrs III and V of the motor area of the cerebral cortex were examined in the young adult mice (30-60 days old) by a modified Golgi-Cox method and laser scanning microscopy on the 1st, 6th, 10th and 12th days after callosotomy. The anterior part of the callosal body, including rostrum, genu and truncus corporis callosi, was sectioned with a razor blade. The numbers of spines on apical dendrites and their oblique branches of pyramidal neurons were counted at the level of layr II for layr III pyramidal neurons and at the level of layr III for layr V pyramidal neurons. The density of spines was increased on all these dendritic parts during 10 days after callosotomy ; the diameters of spine stems and dendrites were also increased. There changes, however, appeared to be transient as they were decreased almost to normal level on the 12th day after callosotomy.