Development of BrdU releasing polymer and its use on radiosensitization of brain tumors : experimental study.
BrdU 释放聚合物的开发及其在脑肿瘤放射增敏中的应用:实验研究。
基本信息
- 批准号:07671549
- 负责人:
- 金额:$ 1.6万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1995
- 资助国家:日本
- 起止时间:1995 至 1996
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Ethylene vinyl acetate copolymer is a convenient vehicle capable of sustained drug release. BrdU,thymidine analogue, is incorporated into S-phase cells and enhances susceptibility of cells to irradiation and UV.However, BrdU was not used generally because of its systemic toxicity. We developed BrdU polymer capable of sustained BrdU release. We applied this polymer to subcutaveous rat 9L glioma and examind radiosensitizing effect of BrdU polymer. However, we did not find difference in tumor size between rats reated by irradiation plus polymer and those treated only by irradiation. The reason why BrdU polymer did not show radiosensitizing effect glioma in vivo is under investigation.
乙烯-醋酸乙烯酯共聚物是一种方便的药物缓释载体。BrdU是一种胸苷类似物,可掺入S期细胞,增强细胞对辐射和紫外线的敏感性,但由于其全身毒性而未被广泛使用。我们开发了能够持续释放BrdU的BrdU聚合物。我们将该聚合物应用于大鼠9 L胶质瘤的皮下移植,并检测了BrdU聚合物的放射增敏作用。然而,我们没有发现放射加聚合物治疗的大鼠和仅用放射治疗的大鼠之间的肿瘤大小的差异。BrdU聚合物在体内胶质瘤中没有放射增敏作用的原因正在调查中。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KAWAMOTO Keiji其他文献
KAWAMOTO Keiji的其他文献
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{{ truncateString('KAWAMOTO Keiji', 18)}}的其他基金
Study for neuronal regeneration in ischemic brain using bone marrow transplantation
骨髓移植促进缺血脑神经元再生的研究
- 批准号:
15591555 - 财政年份:2003
- 资助金额:
$ 1.6万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Functional analysis of p130 oncogene in malignant glioma
恶性胶质瘤p130癌基因的功能分析
- 批准号:
13671475 - 财政年份:2001
- 资助金额:
$ 1.6万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Control of cell cycle phase p130 gene transfaction indicating of cyclin expression in glioma.
细胞周期阶段 p130 基因转染的控制表明神经胶质瘤中细胞周期蛋白的表达。
- 批准号:
11671403 - 财政年份:1999
- 资助金额:
$ 1.6万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The efffect of irradiation on brain microvascular eudotherial cells
辐射对脑微血管真兽细胞的影响
- 批准号:
09671456 - 财政年份:1997
- 资助金额:
$ 1.6万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Detection of chromosome abnomality by fluorescent in situ hybridization in brain tumors.
通过荧光原位杂交检测脑肿瘤中的染色体异常。
- 批准号:
04670877 - 财政年份:1992
- 资助金额:
$ 1.6万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
FLOWCYTOMETRIC ANALYSES OF EXPRESSIONS OF GLYCOPROTEIN ANTIGEN AND EGF-RECEPTORS, AND DNA DISTRIBUTION IN BRAIN TUMORS
脑肿瘤中糖蛋白抗原和 EGF 受体的表达以及 DNA 分布的流式细胞术分析
- 批准号:
02670640 - 财政年份:1990
- 资助金额:
$ 1.6万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Study on Antineoplastic Effects of NK Cells and IL-2 for Malignant Brain Tumors.
NK细胞和IL-2对恶性脑肿瘤的抗肿瘤作用研究。
- 批准号:
60570683 - 财政年份:1985
- 资助金额:
$ 1.6万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)