ヒト大腸電気刺激による脳・腸機能相関の生理と病態生理

人结肠电刺激脑-肠功能相关性的生理学和病理生理学

• 批准号: 07770043
• 负责人: 福土 審
• 金额: $ 0.58万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Encouragement of Young Scientists (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07770043/
• 关键词: 脳腸相関; 過敏性腸症候群; 電気刺激; barostat; 結腸tone; 消化管運動; 痛覚閾値; 大脳誘発電位

研究結果 これまで見出した知見を更に発展させ、正常人(生理)と過敏性腸症候群(irritable bowel syndrome;IBS)患者(病態生理)を比較することによって、電気刺激下の消化管運動と脳機能検査法をヒトで確立した。広告と掲示で募集した健常成人と典型的IBS患者を対象とし、検査日の朝9:00より全例にX線透視下でOlympus社製大腸videoscope CF-200Lを用いて経肛門的にassemblyを下行結腸-S状結腸接合部に留置した。Assemblyは半導体sensorのSynectics社製silicon pressure transducer、barostat、刺激電極からなり、pressure transducerによって、肛門から約60cmの下行結腸(A)、約55cm(B)、50cm(C)のS状結腸の消化管内圧を、barostatによって約65〜45cmの結腸toneを測定した。右上腕に血圧カフ、前胸部に心電図電極、呼吸曲線probe、頭部に脳波電極を装着し、これらをMIC-9800システムポリグラフ、7T18型シグナルプロセッサ、XR-510型データレコーダ、Synectics Visceral Stimulator(SVS)、PC-9801RA21型コンピュータに接続し、生体信号をリアルタイムで導出かつ保存した。この手法により、barostatの膨張で電極が大腸粘膜に密着し、消化管内圧の感度が飛躍的に向上し、大腸の壁在反射を変化させることなく、これまで明らかにされなかった弛緩現象を含む結腸toneを検出し得た。また、Bに接する中央の2つの刺激電極で大腸を電気的に刺激し、結腸toneの変化と大脳誘発電位を検出した。大腸の電気刺激によって結腸toneは僅かに低下し、痛覚閾値は4-20mAであった。大腸拡張刺激による痛覚閾値は正常人よりもIBS患者で低く、大腸運動係数は正常人が拡張刺激による変化に乏しいのに対してIBS患者では亢進しており、大脳誘発電位もIBS患者で短潜時と振幅の増大が見られた。以上、わが平成7年度の課題研究は脳腸機能相関における結腸toneと末梢-中枢プロセシングの生理と病態生理を明らかにしつつあり、一定の成果をおさめることができた。この研究成果の一部は、国内の学会で発表され、国外でも発表される予定である。

Results the results of the study showed that the patients with allergic syndrome (irritable bowel syndrome;IBS) in normal subjects (physiology) were significantly higher than those in normal subjects (physiology). The results of the study showed that the patients with allergic syndrome (irritable bowel syndrome;IBS), normal subjects (physiology) and patients with allergic syndrome (EPS) (pathophysiology) were significantly higher than those in normal subjects (physiology). Notice that typical IBS patients in the recruitment program, healthy adults, are suffering from anal dysphagia at 9:00. The whole Olympus community uses an anal assembly in the Olympus community under X-ray view-the S-shaped junction is placed in the junction. Assembly hemispheres sensor Synectics silicon pressure transducer, barostat, stimulation electrophoretic stimulation (pressure transducer), anal manometry, 60cm descending results (A), about 55cm (B), 50cm (C) S-shaped tests were performed in the digestive tract and barostat were measured by 65~45cm and tone. Blood on the right upper wrist, cardioplegia on the front chest, probe on the respiratory curve, torsion on the side of the chest, device on the MIC-9800, type 7T18 on the chest, type XR- 510 on the chest, Synectics Visceral Stimulator (SVS), type PC- 9801RA21 on the chest, the body signal on the body was detected and the device was saved. The sensitivity of the digestive tract was higher than that of the digestive tract, the sensitivity of the digestive tract was up, the wall of the digestive tract was reflex sensitive, and the wall of the digestive tract was in reflex. The results showed that there was no significant difference between the two groups (P < 0.05). The results showed that the sensitivity of the digestive tract was higher than that of the digestive tract, and that the wall of the digestive tract was reflected in the reflection of the digestive tract. the results showed that the tone showed good results. The radio and the B terminal are connected with the central government to stimulate the active power supply. The results show that the tone changes the output of the electrical potential of the major power station. The results of large-scale electrical stimulation experiments show that the tone levels are low and the pain levels are 4-20mA. The number of IBS patients was lower than that of normal subjects, the number of exercise events of normal people was lower than that of normal subjects, and the amplitude of short latency of patients with IBS was significantly higher than that of patients with IBS. The above, the project research in Pingcheng 7, the computer can compare the results of the tone test, the terminal-central system, the physiology, the physiology, the disease, the physiology, the disease, the disease, the disease, The research results are published in a book, the tables of domestic societies and foreign countries are expected to be published.