Collaborative study for the best treatment of acute leukemia.

在这项研究中，我们比较了日本成人白血病研究小组（JALSG）与国际骨髓移植登记处（IBMTR）和几个国际白血病研究组的治疗结果，通过匹配对分析或最佳治疗的元分析进行了比较。（1）关于已通过JALSG和英国MRC统计中心通过电子邮件、传真和软盘处理的几项协议发送到IBMTR统计中心的Leukemia患者的数据。（2） Japanese investigators visited IBMTR·and participated in the matched-pair analysis of JALSG's adult acute lymphoblastic leukemia patients who received BMT.The results were accepted for publication in Bone Marrow Transplantation。（3）日本调查员访问了联合王国MRC统计中心，并参与了对Leukemia患者的元分析，包括JALSG在内的世界领先的Leukemia研究组，以及关于G-CSF的结果，为出版物做准备。However，关于化疗需要更多讨论的结果，包括由世卫组织提出的项目定义，将继续下去。（4）访问了巴黎大学的日本调查人员，他们就差异化疗法的急性胚胎性白血病，包括基本机制，为什么差异化疗法只对这种白血病有效。（5）一项有益于慢性骨髓瘤白血病的研究结果发表在《国家癌症研究所杂志》上。

In this study, we compared the treatment results of the Japan Adult Leukemia Study Group (JALSG) with those of the International Bone Marrow Transplantation Registry (IBMTR) and of several international leukemia study groups by a matched-pair analysis or a meta-analysis for the best treatment of acute leukemia.(1) Data on leukemia patients who had been treated with several protocols of JALSG were sent to the IBMTR statistical center in USA and the MRC statistical center in UK through E-mail, FAX and floppy discs.(2) Japanese investigators visited IBMTR・and participated in the matched-pair analysis of JALSG's adult acute lymphoblastic leukemia patients with IBMTR's patients who received BMT.The results were accepted for publication in Bone Marrow Transplantation.(3) Japanese investigators visited the MRC statistical center in UK and participated in the meta-analysis of leukemia patients from leading leukemia study groups in the world including JALSG,and the results on G-CSF is in preparation for publication. However, the results on chemotherapy need more discussion including item definition proposed by WHO,which will continue further.(4) Japanese investigators visited University of Paris and had a discussion on the differentiation therapy of acute promyelocytic leukemia including the basic mechanism why the differentiationtherapy is effective only for this leukemia.(5) The result of a study concomitantly done for chronic myeloid leukemia was published in the Journal of National Cancer Institute.