Collaborative study for the best treatment of acute leukemia.

急性白血病最佳治疗的合作研究。

• 批准号: 08044265
• 负责人: OHNO Ryuzo
• 金额: $ 4.1万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08044265/
• 关键词: acute leukemia; chemotherapy; bone marrow transplantation; differentiation therapy; matched-pair analysis; meta-analysis; JALSG; acute promyelocytic leukemia; 急性リンパ性白血病; 急性骨髄性白血病; matched-pair analysis; メタアナリス; IBMTR; MRC

In this study, we compared the treatment results of the Japan Adult Leukemia Study Group (JALSG) with those of the International Bone Marrow Transplantation Registry (IBMTR) and of several international leukemia study groups by a matched-pair analysis or a meta-analysis for the best treatment of acute leukemia.(1) Data on leukemia patients who had been treated with several protocols of JALSG were sent to the IBMTR statistical center in USA and the MRC statistical center in UK through E-mail, FAX and floppy discs.(2) Japanese investigators visited IBMTR・and participated in the matched-pair analysis of JALSG's adult acute lymphoblastic leukemia patients with IBMTR's patients who received BMT.The results were accepted for publication in Bone Marrow Transplantation.(3) Japanese investigators visited the MRC statistical center in UK and participated in the meta-analysis of leukemia patients from leading leukemia study groups in the world including JALSG,and the results on G-CSF is in preparation for publication. However, the results on chemotherapy need more discussion including item definition proposed by WHO,which will continue further.(4) Japanese investigators visited University of Paris and had a discussion on the differentiation therapy of acute promyelocytic leukemia including the basic mechanism why the differentiationtherapy is effective only for this leukemia.(5) The result of a study concomitantly done for chronic myeloid leukemia was published in the Journal of National Cancer Institute.

在这项研究中，我们通过配对分析或Meta分析比较了日本成人白血病研究小组(JALSG)与国际骨髓移植登记中心(IBMTR)和几个国际白血病研究小组的治疗结果，以确定急性白血病的最佳治疗方案。(1)将接受JALSG几种方案治疗的白血病患者的数据通过电子邮件发送到美国的IBMTR统计中心和英国的MRC统计中心，(2)日本研究人员访问了IBMTR·，并参与了JALSG的成人急性淋巴细胞白血病患者与接受骨髓移植的IBMTR患者的配对分析，结果被接受发表在骨髓移植杂志上。(3)日本研究人员访问了英国的MRC统计中心，并参与了包括JALSG在内的世界领先白血病研究小组的白血病患者的荟萃分析，关于G-CSF的结果正在准备发表中。然而，关于化疗的结果还需要更多的讨论，包括WHO提出的项目定义，这将继续下去。(4)日本研究人员访问巴黎大学，就急性早幼粒细胞白血病的分化治疗进行了讨论，包括分化治疗仅对该白血病有效的基本机制。(5)同时进行的一项针对慢性髓细胞白血病的研究结果发表在国家癌症研究所杂志上。

项目成果

Kanamaru,A., Ohno,R.et al.: "All-trans retinoic acid for the treatment of newly diagnosed acute promyelocytic leukemia." Blood. 85. 1202-1206 (1995)

Kanamaru,A.、Ohno,R.等人：“全反式视黄酸用于治疗新诊断的急性早幼粒细胞白血病。”

Takeshita,A.,Ohno,R.et al.: "Successful treatment of relapse of acute promyelocytic leukemia with a new synthetic retinoid, Am80." Ann.Intern.Med. 124. 893-896 (1996)

Takeshita,A.,Ohno,R.等人：“用新的合成类视黄醇 Am80 成功治疗了急性早幼粒细胞白血病的复发。”

Ohno R., Miyawaki S. et al.: "Human urinary macrophage colony-stimulating factor reduces the incidence and duration of febrile neutropenia and shortens the period required to finish three courses of intensive consolidation therapy in acute myeloid leukemi

Ohno R.、Miyawaki S. 等人：“人尿巨噬细胞集落刺激因子可降低发热性中性粒细胞减少症的发生率和持续时间，并缩短急性髓系白血病完成三个疗程强化巩固治疗所需的时间

Oh H,,Ohno R. et al.: "Chemotherapy versus HLA-identical sibling transplants for adults with acute lymphoblastic leukemia in first remission" Bone Marrow Transplantation. 21(印刷中). (1998)

Oh H,,Ohno R. 等人：“首次缓解的成人急性淋巴细胞白血病的化疗与 HLA 相同同胞移植”，骨髓移植 21（出版中）。

Tobita, T., Ohno, R.et al.: "Treatment with a new synthetic retinoid, Am80, of acute promyelocyticleukemia relapsed from complete remission induced by all-trans retinoic acid." Blood. 90(3). 967-973 (1997)

Tobita, T.、Ohno, R.等人：“用新型合成类视黄醇 Am80 治疗急性早幼粒细胞白血病，由全反式视黄酸诱导的完全缓解后复发。”