DRUGMONITORING OF ANTI-CANCER DRUG USING RADIONUCLIDES -APPLICATION FOR TDM OF MULTI-DRUG CHEMOTHERAPY-

点击翻译按钮获取中文摘要

The aim of this research was as follows :1) Development of ^<111>In labeled Adriamycin as a new agent2) Research of ^<111>In labeled Taxol using tumor bearing mice3) Experiment of ^<123>I-EU using tumor bearing mice4) Research of radiosynthesis of ^<111>In-Tamoxifen and experimental evaluation of its biodistribution5) Research of radiosynthesis of ^<18>F-5FU and experimental evaluation of its biodistributionRadiosynthesis of five different radiolabelled anticancer drugs as described above was succeeded and the biodistribution of ^<111>In labeled Taxol, ^<123>I-EU,and^<18>F-5FU were assessed using tumor bearing mice. The relationships between the concentration of radiolaballed anticancer drugs and the effectiveness on tumor-response of corresponding ant-cancer drugs were not clear. However results of biodistribution obtained in this study encouraged us to use the radiolabelled anti-cancer drugs clinically.