DRUGMONITORING OF ANTI-CANCER DRUG USING RADIONUCLIDES -APPLICATION FOR TDM OF MULTI-DRUG CHEMOTHERAPY-

使用放射性核素进行抗癌药物的药物监测 - 多药物化疗 TDM 的应用 -

• 批准号: 08671006
• 负责人: INOUE Tomio
• 金额: $ 1.54万
• 依托单位: GUNMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671006/
• 关键词: RADIONUCLIDES; TDM; MULTIDRUG CHEMOTHERAPY; ANTI-CANCER DRUG; CANCER TREATMENT; RI標識治療薬; ^<123>I-Tamoxifen; 1-123EU; _<111>In-Taxol

The aim of this research was as follows :1) Development of ^<111>In labeled Adriamycin as a new agent2) Research of ^<111>In labeled Taxol using tumor bearing mice3) Experiment of ^<123>I-EU using tumor bearing mice4) Research of radiosynthesis of ^<111>In-Tamoxifen and experimental evaluation of its biodistribution5) Research of radiosynthesis of ^<18>F-5FU and experimental evaluation of its biodistributionRadiosynthesis of five different radiolabelled anticancer drugs as described above was succeeded and the biodistribution of ^<111>In labeled Taxol, ^<123>I-EU,and^<18>F-5FU were assessed using tumor bearing mice. The relationships between the concentration of radiolaballed anticancer drugs and the effectiveness on tumor-response of corresponding ant-cancer drugs were not clear. However results of biodistribution obtained in this study encouraged us to use the radiolabelled anti-cancer drugs clinically.

本研究的目的如下：1)新药剂^<111>In标记阿霉素的开发2)载瘤小鼠对^<111>In标记紫杉醇的研究3)载瘤小鼠对^<123>I-EU的实验4)In- tamoxifen ^<111>的放射合成及其生物分布的实验评价5)^<18>F-5FU的放射合成及其生物分布的实验评价5种不同的放射性标记抗癌药物的放射性合成用荷瘤小鼠对^<111>In标记紫杉醇、^<123>I-EU和^<18>F-5FU的生物分布进行了评价。放射性抗癌药物的浓度与相应抗癌药物的肿瘤反应效果之间的关系尚不清楚。然而，本研究获得的生物分布结果鼓励我们在临床上使用放射性标记抗癌药物。

项目成果

T.Inoue: "Evaluation of [^3I]iodoerythronitroimidazole as a predictor for the radiosensitizing effect." AAnti-Cancer Drugs. 7. 858-865 (1996)

T.Inoue：“[^3I]碘赤硝基咪唑作为放射增敏作用预测因子的评估。”

T.Inoue: "Evaluation of [^<131>I] iodoerythronitroimidazole as a predictor for the radiosensitizing effect." Anti-cancer Drugs. Vol 7. 858-865 (1996)

T.Inoue：“评估[^<131>I]碘赤硝基咪唑作为放射增敏作用的预测因子。”

T.Inoue: "Evaluation of [^<111>I] iodoerythronitroimidazole as a predictor for the radiosensitizing effect." AAnti-Cancer Drugs. 7. 858-865 (1996)

T.Inoue：“评估[^<111>I]碘赤硝基咪唑作为放射增敏作用的预测因子。”

T.Inoue: "Positron emission tomography using [^<18>F]fluorotamoxifen to evaluate therapeutic responses in patients with breast cancer:Preliminarystudy." Cancer Biotherapy & Radiopharmaceuticals. 11. 235-245 (1996)

T.Inoue：“使用[^ 18 F]氟他莫昔芬的正电子发射断层扫描来评估乳腺癌患者的治疗反应：初步研究。”

K.Tomiyoshi: "Synthesis of isomers of ^<18>F-labelled amino acid radiopharmaceutical : Position 2-and 3-L-^<18>F-α-methyltyrosine using a separation and purification system." Nuclear Medicine Communications. 18. 169-175 (1997)

K. Tomiyoshi：“使用分离和纯化系统合成^ 18 F标记的氨基酸放射性药物的异构体：2-和3-L-^ 18 F-α-甲基酪氨酸。” .169-175 (1997)