MONITORING OF CANCER THERAPY USING F-18 LABELLED AMINOACID

使用 F-18 标记氨基酸监测癌症治疗

• 批准号: 10670824
• 负责人: INOUE Tomio
• 金额: $ 1.15万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670824/
• 关键词: FMT; FDG; PET; CANCER TREATMENT; AMINO ACID; F-18 アルファメチル タイロシン

F-18 alphamethyl tyrosine (FMT), which was developed in our institute, is one of F-18 labeled amino acids reflecting the amino acid metabolism in the tumor. The aim of this study was to investigate the potential utility of FMT as a marker for monitoring cancer response to therapy as chemotherapy or radiation therapy by conducting animal experiments and clinical trial.In animal experiments, FDG, C-11 methionine, and FMT were injected into LS180 colorectal carcinoma bearing mice to measure the tumor uptake at pre-treatment, 24-hr postinjection, and 7 days postinjection of 5-FU. All tracers accumulated in the tumor at pre-treatment period and significant reduction at 24hr postinjection when tumors did not change in size. Based on these results of animal experiments, clinical comparative studies of FDG and FMT PET were conducted in 8 lung cancer pts (3 small cell cancer, 5 non-small cell cancer), and 4 pts with benign lesions (2 sarcoidosis and 2 mycobacterium avium complex). In lung cancer pts, FDG uptake in the primary lesions was higher than FMT uptake. However FDG showed also high uptake in benign lesions. The differentiation between malignancy and benignancy using FMT-PET seemed to be better than that using FDG-PET. In 3 pts with small all cancer PET underwent 3 times at pre-treatment, 1 week, and 4 week in the course of chemotheray. Even if three pts showed complete remission, partial remission, and no change respectively, FDG showed markedly reduction during the therapy in all 3 pts. The change in FMT uptake during therapy predicted the final response to chemo-therapy in all 3 patients.

18氟甲基酪氨酸（FMT）是我所研制的一种能反映肿瘤氨基酸代谢的18氟标记氨基酸。本研究通过动物实验和临床试验，探讨FMT作为肿瘤化疗或放疗反应监测指标的可能性，在动物实验中，将FDG、C-11蛋氨酸和FMT分别注射到LS 180结直肠癌荷瘤小鼠体内，测定治疗前、注射后24小时、注射5-FU后7天。所有示踪剂在治疗前阶段在肿瘤中积累，并且在注射后24小时显著减少，此时肿瘤大小没有变化。在此基础上，对8例肺癌患者（3例小细胞癌，5例非小细胞癌）和4例良性病变患者（2例结节病，2例鸟分枝杆菌复合体）进行了FDG和FMT PET的临床对比研究。在肺癌患者中，原发病灶的FDG摄取高于FMT摄取。但良性病变FDG也显示高摄取。FMT-PET在鉴别良恶性方面优于FDG-PET。3例小全癌患者分别于化疗前、化疗1周、化疗4周行3次PET检查。即使3例患者分别表现为完全缓解、部分缓解和无变化，但3例患者治疗期间FDG均显示明显降低。治疗期间FMT摄取的变化预测了所有3例患者对化疗的最终反应。

项目成果

Shigeko Amano.: "In vivo comparison of PET and SPECT radiopharmaceuticals in detecting breast cancer."J.Nucl.Med.. 39. 1424-1427 (1998)

Shigeko Amano.：“PET 和 SPECT 放射性药物检测乳腺癌的体内比较。”J.Nucl.Med.. 39. 1424-1427 (1998)

Shigeko Amano: "In vivo comparison of PET and SPECT radiopharmaceuticals in detecting breast cancer" The Journal of Nuclear Medicine. 39. 1424-1427 (1998)

Shigeko Amano：“PET 和 SPECT 放射性药物检测乳腺癌的体内比较”《核医学杂志》。

Saleh Alyafei: "Image fusion system using PACS for MRI, CT and PET images"Clinical Positron Imaging. 2. 137-143 (1999)

Saleh Alyafei：“使用 PACS 进行 MRI、CT 和 PET 图像的图像融合系统”临床正电子成像。

Tomio Inoue.: "Accuracy of standardized uptake value measured by simultaneous emission and transmission scanning in PET oncology."Nuclear Medicine Communications. 20. 849-857 (1999)

Tomio Inoue.：“PET 肿瘤学中通过同步发射和传输扫描测量的标准化摄取值的准确性。”核医学通讯。

Saleh Alyafei.: "Image fusion system using PACS for MRI, CT and PET images."Clinical Positron Imaging. 2. 137-143 (1999)

Saleh Alyafei.：“使用 PACS 进行 MRI、CT 和 PET 图像的图像融合系统。”临床正电子成像。