Dendritic signal processing in the trigeminal motoneurons

三叉神经运动神经元的树突信号处理

• 批准号: 23592750
• 负责人: INOUE Tomio
• 金额: $ 3.33万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592750/
• 关键词: 口腔生理学; 咀嚼; 脳幹スライス標本; 三叉神経運動ニューロン; 樹状突起; ケージドグルタミン酸; カルシウムチャネル; カルシウムイオン動態; 二光子励起顕微鏡; 情報処理; 運動ニューロン; カルシウムイオン; 三叉神経; ２光子励起顕微鏡

The dendrites of neurons have long been considered as electrically passive structures that merely transmit synaptic potentials to the soma. However, the recent studies have shown that the dendrites of some neurons are not only passive but also contain voltage-sensitive conductances that cause an excitation and affect synaptic integration. In this study, we used the two-photon calcium imaging techniques to explore the active dendritic properties in response to the action potentials (APs) in soma of trigeminal motoneurons. We found that the dendrites of trigeminal motoneurons have active properties that could serve as the amplification and modification of synaptic inputs and the regulation of dendritic excitability contribute to the prevention of irregular excitability of trigeminal motoneurons in pathological conditions such as bruxism.

长期以来，神经元的树突一直被认为是电被动结构，只是将突触电位传递到胞体。然而，最近的研究表明，一些神经元的树突不仅是被动的，而且含有引起兴奋并影响突触整合的电压敏感电导。在这项研究中，我们使用双光子钙成像技术来探索三叉神经运动神经元胞体内动作电位(AP)反应的活性树突特性。我们发现，三叉神经运动神经元的树突具有放大和修饰突触输入的活性，树突兴奋性的调节有助于防止三叉神经运动神经元在磨牙症等病理条件下的不规则兴奋性。

项目成果

Functional interactions between the respiratory center, the upper spinal cord, and the trigeminal system.

呼吸中枢、上脊髓和三叉神经系统之间的功能相互作用。

• 发表时间: 2013
• 作者: Yazawa I;Tachikawa S;Mochizuki A;Inoue T;Nakayama K
• 通讯作者: Nakayama K

Neural mechanisms controlling jaw and tongue movements.

控制下巴和舌头运动的神经机制。

• 发表时间: 2013
• 作者: Inoue T;Nonaka M;Ihara Y;Nakamura S;Nakayama K;Yazawa I;Mochizuki A
• 通讯作者: Mochizuki A

Coordination of NMDA-induced rhythmic activity in the trigeminal and hypoglossal nerves of neonatal mice in vitro

• DOI: 10.1016/j.neures.2012.11.003
• 发表时间: 2013-02-01
• 期刊: NEUROSCIENCE RESEARCH
• 影响因子: 2.9
• 作者: Ihara, Yoshiaki;Nakayama, Kiyomi;Inoue, Tomio
• 通讯作者: Inoue, Tomio

Convergent premotoneuronal inputs to single trigeminal motoneurons.

将前运动神经元输入汇聚到单个三叉神经运动神经元。

• DOI: 10.1177/0022034512453724
• 发表时间: 2012
• 期刊: J Dent Res
• 影响因子: 7.6
• 作者: Nonaka M;Nishimura A;Nakamura S;Nakayama K;Mochizuki A;Iijima T and Inoue T.
• 通讯作者: Iijima T and Inoue T.

三叉神経運動ニューロン樹状突起における情報処理機構

三叉神经运动神经元树突的信息处理机制

• 发表时间: 2012
• 作者: Yoshimura K;Miyamoto Y;Yasuhara R;Maruyama T;Akiyama T;Yamada A;Takami M;Suzawa T;Tsunawaki S;Tachikawa T;Baba K;Kamijo R;Suzuki T and Inouye S;中村史朗ほか
• 通讯作者: 中村史朗ほか