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Network of Endocrine Disruptor Research in Japan

日本内分泌干扰物研究网络

基本信息

批准号：
10600001
负责人：
IGUCHI Taisen
金额：
--
依托单位：
Yokohama City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至无数据
项目状态：
已结题

项目摘要

Numerous chemicals, pesticides, materials for plastics and detergents having estrogenic activity, have been released into the environment. These chemicals have potential to disrupt the development and function of the endocrine system in wildlife and humans, being called as endocrine disruptors (EDs). There is a hypothesis that EDs may related to decrease in population of wildlife, increase in breast cancer, endometriosis, testicular cancer and decrease in sperm count in humans, since these chemicals may bind to estrogen receptors and thus evoke estrogenic effects in animals and humans. We need to know the levels of EDs in the environment and potential effects on wildlife and humans. The present research was aimed at making a research group studying EDs in various aspects and recruit researchers from various research fields to share common interests. We organized public symposium on EDs in Yokohama. In zoology, Iguchi, Mori and Wada made a research groups to study effects of EDs on development and reproduction on animals. In fisheries, Hara made a research group to study usefulness of vitellogenin in monitoring of fish in river and sea. In pharmacology, Naganuma made a group to study the ecological effect of persistent pollutants. In agriculture and environmental science, Tanabe and Manabe made a group to study EDs effects on marine mammals and malformations. In medicine, Mori and Nagayama made a group to study EDs effects on fetus and human reproduction. Umesono and Sato studied made a group to study action mechanism of EDs. In technology, Matsui made group to study sewage treatment. Each research group is unique and these research groups work hard to solve endocrine disruptor issue and suggest how to control chemical release in the environment and reduce adverse effects on wildlife and humans by EDs.

许多具有雌激素活性的化学品、杀虫剂、塑料材料和洗涤剂被释放到环境中。这些化学物质有可能破坏野生动物和人类内分泌系统的发育和功能，被称为内分泌干扰物（EDs）。有一种假设认为，ed可能与野生动物数量减少、乳腺癌、子宫内膜异位症、睾丸癌和人类精子数量减少有关，因为这些化学物质可能与雌激素受体结合，从而在动物和人类中引起雌激素效应。我们需要知道环境中ed的含量以及对野生动物和人类的潜在影响。本研究旨在建立一个研究EDs各方面的研究小组，并招募来自不同研究领域的研究人员来分享共同的兴趣。我们在横滨组织了关于EDs的公开研讨会。在动物学方面，Iguchi， Mori和Wada组成了一个研究小组，研究ed对动物发育和繁殖的影响。在渔业方面，原教授成立了一个研究小组，研究卵黄原蛋白在江河和海洋鱼类监测中的作用。在药理学方面，Naganuma做了一个小组来研究持久性污染物的生态效应。在农业和环境科学方面，Tanabe和Manabe组成了一个小组，研究EDs对海洋哺乳动物和畸形的影响。在医学方面，Mori和Nagayama组成了一个小组，研究EDs对胎儿和人类生殖的影响。Umesono和Sato研究了EDs的作用机理。在技术上，松井组成小组研究污水处理。每个研究小组都是独特的，这些研究小组努力解决内分泌干扰物问题，并提出如何控制化学物质在环境中的释放，减少ed对野生动物和人类的不利影响。