Network of Endocrine Disruptor Research in Japan

许多具有雌激素活性的化学品、杀虫剂、塑料材料和洗涤剂已被释放到环境中。这些化学物质有可能破坏野生动物和人类内分泌系统的发育和功能，被称为内分泌干扰物（EDs）。有一种假说认为，ED可能与野生动物数量减少，乳腺癌，子宫内膜异位症，睾丸癌和人类精子数量减少有关，因为这些化学物质可能与雌激素受体结合，从而引起动物和人类的雌激素效应。我们需要知道环境中的ED水平以及对野生动物和人类的潜在影响。本研究的目的是建立一个多方面研究ED的研究小组，并招募来自不同研究领域的研究人员，以分享共同的兴趣。我们在横滨举办了关于ED的公开研讨会。在动物学方面，井口、森和田等人组成了一个研究小组，研究ED对动物发育和繁殖的影响。在渔业方面，原建立了一个研究小组，研究卵黄蛋白原在监测河流和海洋鱼类中的有用性。在药理学方面，长沼建立了一个小组，研究持久性污染物的生态效应。在农业和环境科学方面，田边和真锅组成了一个小组，研究EDs对海洋哺乳动物和畸形的影响。在医学方面，Mori和Nagayama组成了一个小组，研究ED对胎儿和人类生殖的影响。Umesono和Sato等人组成了一个研究小组来研究ED的作用机制。在技术上，松井组成小组研究污水处理。每个研究小组都是独一无二的，这些研究小组努力解决内分泌干扰物问题，并建议如何控制环境中的化学品释放，减少ED对野生动物和人类的不利影响。

Numerous chemicals, pesticides, materials for plastics and detergents having estrogenic activity, have been released into the environment. These chemicals have potential to disrupt the development and function of the endocrine system in wildlife and humans, being called as endocrine disruptors (EDs). There is a hypothesis that EDs may related to decrease in population of wildlife, increase in breast cancer, endometriosis, testicular cancer and decrease in sperm count in humans, since these chemicals may bind to estrogen receptors and thus evoke estrogenic effects in animals and humans. We need to know the levels of EDs in the environment and potential effects on wildlife and humans. The present research was aimed at making a research group studying EDs in various aspects and recruit researchers from various research fields to share common interests. We organized public symposium on EDs in Yokohama. In zoology, Iguchi, Mori and Wada made a research groups to study effects of EDs on development and reproduction on animals. In fisheries, Hara made a research group to study usefulness of vitellogenin in monitoring of fish in river and sea. In pharmacology, Naganuma made a group to study the ecological effect of persistent pollutants. In agriculture and environmental science, Tanabe and Manabe made a group to study EDs effects on marine mammals and malformations. In medicine, Mori and Nagayama made a group to study EDs effects on fetus and human reproduction. Umesono and Sato studied made a group to study action mechanism of EDs. In technology, Matsui made group to study sewage treatment. Each research group is unique and these research groups work hard to solve endocrine disruptor issue and suggest how to control chemical release in the environment and reduce adverse effects on wildlife and humans by EDs.