ABNORMALITY OF COGNITION IN SCHIZOTYPAL PERSONALITY DISORDER FROM THE ASSESSMENTS OF EVENT-RELATED POTENTIALS AND CEREBRAL HEMODYNAMICS

从事件相关电位和脑血流动力学评估看精神分裂型人格障碍的认知异常

• 批准号: 10670908
• 负责人: OGURA Chikara
• 金额: $ 0.13万
• 依托单位: UNIVERSITY OF THE RYUKYUS
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670908/
• 关键词: Schizotypal Personality Disorder; ERPs; f-NIRS; P300

Biological, phenomenological and cognitive similarities are known to exist between schizophrenia and schizophrenia-spectrum disorders. This study examined whether abnormalities in event-related potentials (ERPs) reported in schizophrenia can also be observed in persons with Schizotypal Personality Disorder (SPD). ERPs were examined in 9 subjects and 9 controls recruited from among 1693 college students using the Schizotypal Personality Questionnaire (SPQ) and the Structured Clinical Interview for DSM-III-R (SCID). In addition f-NIRS (functional Near Infrared Spectroscopy) examination was undertaken in a subject of SPD. ERPs were recorded during an auditory oddball task. The peak latencies and amplitudes for N100, P200, N200 and P300 were measured. No difference was detected in P200, N200 and P300 latencies or in the latency or amplitude of N100 components between the two groups. Reduced P200 and P300 amplitudes and increased N200 amplitudes were found in SPD subjects. We calculated that a smaller N2b amplitude existed in the SPD subjects. LORETA (Low Resolution Electro-magnetic Tomography) analysis showed reduced cortical activity related to P300 and N2b in SPD subjects. f-NIRS showed normal response to the task (Mirror Drawing Task) in a SPD subject. Our findings suggest that smaller P300 and N2b amplitudes might be considered trait markers for schizophrenia and since SPD subjects showed deficits in information processing and attention, they may be at risk for developing schizophrenia or schizophrenia-like psychoses.

已知精神分裂症和精神分裂症谱系障碍之间存在生物学、现象学和认知相似性。本研究旨在探讨精神分裂症患者的事件相关电位（ERP）异常是否也可以在分裂型人格障碍（SPD）患者中观察到。采用分裂型人格问卷（SPQ）和DSM-III-R结构化临床访谈（SCID）对1693名大学生中的9名被试和9名对照者进行了ERPs检测。此外，在SPD受试者中进行了f-NIRS（功能性近红外光谱）检查。ERPs记录在一个听觉oddball任务。测量N100、P200、N200和P300的峰值潜伏期和振幅。两组P200、N200、P300潜伏期及N100各成分的潜伏期、波幅均无差异。SPD组P200、P300波幅降低，N200波幅增高。我们计算出一个较小的N2 b振幅存在于SPD的主题。LORETA（低分辨率电磁断层扫描）分析显示，SPD受试者与P300和N2 b相关的皮质活动减少。在SPD受试者中，f-NIRS显示对任务（镜像绘制任务）的正常反应。我们的研究结果表明，较小的P300和N2 b振幅可能被认为是精神分裂症的特质标志，因为SPD受试者在信息处理和注意力方面表现出缺陷，他们可能有患精神分裂症或精神分裂症样精神病的风险。