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Organic Chemistry of Nitric Oxide for the Understanding of Its Physiological Roles

一氧化氮的有机化学有助于理解其生理作用

基本信息

批准号：
10671996
负责人：
ITOH Takashi
金额：
$ 1.66万
依托单位：
Showa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

Despite its simple structure, nitric oxide (NO) has been found to play diverse roles in biological systems. Accompanied by the positive physiological roles, NO causes extensive damage to the body in the case that NO is released at relatively higher concentration. In these circumstances, NO is activated by the reaction with various active oxygens to afford more reactive nitrogen oxides, and the ultimate reactive species included in the processes has been an important target for toxicological studies.For the understanding of reactive species of nitrogen oxides toward organic molecules, we have recently been studying the reaction of nitric oxide with nitrogen compounds in the presence and absence of oxygen, and found that oxygen plays two type of roles in this system, that is, one in which oxygen is consumed according to a stoichiometry, and the other where oxygen functions in a catalytic manner. With these results in hand, we next applied the reaction system to development of a new methodology of nitric oxide quenching, and found that N-aminoazaaromatics reacted rapidly with NO in the presence of various amounts of oxygen to afford corresponding deaminated products in quantitative yields. NO or higher nitrogen oxides was transformed stoichiometrically to nitrous oxide NィイD22ィエD2O. In addition, N-aminoazole derivatives were also found to quench superoxide anion, which is a precursor of peroxynitrite and other active oxygen species.

尽管一氧化氮（NO）结构简单，但已发现其在生物系统中发挥多种作用。NO具有积极的生理作用，当NO以较高浓度释放时，会对机体造成广泛的损伤。在这些情况下，NO通过与各种活性氧反应而被活化，以提供更具活性的氮氧化物，并且在该过程中包括的最终活性物种一直是毒理学研究的重要目标。为了理解氮氧化物对有机分子的活性物种，我们最近一直在研究一氧化氮与氮化合物在存在和不存在氧的情况下的反应，并发现氧在该系统中起两种类型的作用，即，一种是氧根据化学计量消耗，另一种是氧以催化方式起作用。有了这些结果在手，我们接下来应用该反应体系开发一种新的方法，一氧化氮淬灭，并发现，N-氨基氮杂芳烃与NO在存在的各种量的氧气，以提供相应的脱氨基的产品在定量产率的快速反应。NO或更高浓度的氮氧化物按化学计量转化为一氧化二氮NイD22 D2 O。此外，还发现N-氨基唑衍生物可以淬灭超氧阴离子，超氧阴离子是过氧亚硝酸根和其他活性氧物种的前体。