The advantages and/or Disadvantages of exercise and dietary therapies on diabetic nephroupathy.

比较运动和饮食治疗对糖尿病肾病（DN）的预防作用。将32只雄性OLETF大鼠分为4组（Ex、Diet、Sed、Pre）。14只LETO大鼠作为正常对照。22 ~ 31周治疗10周。Ex组进行自愿运动训练，节食组限制食物摄入，使体重与Ex组相当。与饮食组相比，Ex组尿白蛋白排泄量显著增加，但明显低于Sed组。在治疗期间，Ex组的血压有升高的趋势。Ex组和Diet组的体重和血脂显著降低，葡萄糖耐受不良得到改善。饲粮组和EX组的代谢指标无显著差异。EX组肾脏重量明显加重，肾小球面积和体积增大。运动通过改善代谢紊乱对DN的保护作用可能被运动引起的肾负荷所抵消。在运动治疗中，控制运动强度和血压以及改善葡萄糖耐受不良和脂质代谢似乎是重要的。

The effects of exercise and dietary therapy on the prevention of diabetic nephropathy (DN) were compated. Thirty-two male OLETF rats were divided into four groups (Ex, Diet, Sed, Pre). Fourteeen LETO rats served as the normal controls. Therapy was conducted for 10 weeks from age 22 to 31 weeks. The Ex group was trained by voluntary exercise, and the Diet group had a restricted food intake resulting in the same body weight (BW) as that of the Ex group. The Ex developed significant increase in urinary albumin excretion compared to the Diet group, although significantly less than the Sed group. Blood pressure in the Ex group showed a tendency to be higher during therapy. BW and serum lipids were significantly reduced, and glucose intolerance was improved in both the Ex and Diet gruoups. There were no differences in the metabolic indices between the EX and Diet groups. The EX group showed a significantly heavier kidney weight and a tendency for enlargement of the glomerular area and volume. The protective effect on DN through improvement of the metabolic disorder by exercise might be offset by exercise-induced renal loads. Control of exercise intensity and blood pressure appear to be important as well as the improvement of glucose intolerance and lipid metabolisms in exercise therapy on DN.