Effects of exercise and food restriction during childhood on the set point for body weight in genetically obese OLETF rats

本研究旨在探讨儿童时期体力活动减少导致的能量消耗减少或儿童时期暴饮暴食导致的能量摄入量增加是否是重新设定体重(BW)的原因。实验结束时，运动组的瘦体重(LBM)、能量代谢相关酶如CS、SDH和PFK以及UCP-3mRNA的表达显著高于节食组和久坐组。目前的研究表明，通过在儿童时期进行定期锻炼来防止体重增加，有助于增加骨骼肌质量和能量消耗。此外，早期运动可能有助于在遗传上易患肥胖症的人中重新设定体重设定点。

The present study was conducted to examine whether a decrease in energy expenditure caused by reduced physical activity during childhood or an increase in energy intake caused by overeating during childhood was responsible for resetting the set point for body weight(BW). At the completion of the experiment, lean body mass(LBM); energy metabolism-related enzymes such as CS, SDH, and PFK ; and UCP-3mRNA expression were significantly higher in the exercise group than in the diet-restriction and sedentary groups. The present study suggests that prevention of BW gain by performing regular exercise during childhood contributes to increased skeletal muscle mass and enhanced energy expenditure. Further, early-onset exercise may contribute to resetting the set point for BW in individuals genetically predisposed to obesity.