Effects of exercise and food restriction during childhood on the set point for body weight in genetically obese OLETF rats

本研究旨在研究儿童时期体力活动减少导致的能量消耗减少，或儿童时期暴饮暴食导致的能量摄入增加，是否对体重设定值（BW）的重置负责。实验完成时，瘦体质量（LBM）；与能量代谢相关的酶，如CS、SDH和PFK；运动组的UCP-3mRNA表达明显高于节食组和久坐组。目前的研究表明，通过在儿童时期进行有规律的运动来预防体重增加有助于增加骨骼肌质量和增加能量消耗。此外，早发性运动可能有助于重置肥胖遗传易感性个体的体重设定值。

The present study was conducted to examine whether a decrease in energy expenditure caused by reduced physical activity during childhood or an increase in energy intake caused by overeating during childhood was responsible for resetting the set point for body weight(BW). At the completion of the experiment, lean body mass(LBM); energy metabolism-related enzymes such as CS, SDH, and PFK ; and UCP-3mRNA expression were significantly higher in the exercise group than in the diet-restriction and sedentary groups. The present study suggests that prevention of BW gain by performing regular exercise during childhood contributes to increased skeletal muscle mass and enhanced energy expenditure. Further, early-onset exercise may contribute to resetting the set point for BW in individuals genetically predisposed to obesity.