Effect of exercise therapy on diabetic nephropathy (DN). -Glucose-fatty metabolism, renal function and morphological findings in the kidney of OLETF rats as a model of type 2 diabetes mellitus-

运动疗法对糖尿病肾病（DN）的影响。

• 批准号: 12680052
• 负责人: SUZUKI Masato
• 金额: $ 2.18万
• 依托单位: JIKEI UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12680052/
• 关键词: diabetic nephropathy; NIDDM model rat; exercise intensity; treadmill run; urinary albumin; glucose tolerance test; blood pressure; body weight; 運動療法; 尿中アルプミン排泄量

The present study was conducted to examine the effects Of exercise intensity on physical fitness, glucose-fatty metabolism, kidney weight and albumin excretion into the urine (uA1b). Thirty-six OLETF rats were divided into four groups (Low, Mode, High intensity, and Sed control ). An animal treadmill was used for exercise therapy, which consisted of three intensities : Low (12 m/ mm), Mode (16.5 rn/mm) and High (21.5 m/min). The exercise time was 60 min per exercise bout. The frequency was 5 days per week. The duration of the program was 10 weeks. Oxygen intake during increasing work load exercise was measured using metabolic chamber attached to the treadmill, and oral glucose tolerance tests (glu.2g/kgBW) were also conducted before and after the therapy. Increases in physical fitness, skeletal muscle mass and decreases in BW, fat mass, and serum TG and TC depended on increasing the intensity. Improvement in glucose intolerance (GI) and inhibition of uA1b were carried out by exercise therapy, but no differences were seen among these three intensities. Kidney weight, uNAG and thickness of GBM increased with dependance on increase in exercise intensity. It was suggested that greater improvement of GI was important for the protective effect of DN than improvement of fatty metabolism. Low intensity, longer duration of the exercise bout , and more frequent exercise therapy appeared to be important as well as the control of food intake to prevent the occurence and development of DN.

本研究旨在探讨运动强度对体质、糖脂代谢、肾重和尿白蛋白排泄量（uA 1b）的影响。将36只OLETF大鼠分为4组（低强度、模式、高强度和Sed对照）。动物跑步机用于运动治疗，其包括三种强度：低（12 m/min）、模式（16.5 m/min）和高（21.5 m/min）。每次运动时间为60 min。频率为每周5天。该计划的持续时间为10周。在递增负荷运动中用运动代谢舱测定氧摄入量，并在治疗前后进行口服葡萄糖耐量试验（glu.2g/kgBW）。增加体能，骨骼肌质量和体重，脂肪量，血清TG和TC的下降依赖于增加强度。通过运动疗法改善葡萄糖耐量（GI）和抑制uA 1b，但在这三种强度之间没有差异。随着运动强度的增加，肾重、尿NAG和GBM厚度增加。提示改善胃肠道指数比改善脂肪代谢对DN的保护作用更重要。低强度、长时间的运动和频繁的运动治疗以及控制饮食是预防DN发生和发展的重要措施。

项目成果

鈴木政登, 穂積典子, 他.: "糖尿病モデルOLETFラットに対する運動療法の影響-糖脂質代謝能,組織脂質含量および腎機能に及ぼす強度の影響-"第55回日本体力医学会総会にて発表. (2001)

Masato Suzuki、Noriko Hozumi 等人：“运动疗法对糖尿病模型 OLETF 大鼠的影响 - 强度对糖脂代谢能力、组织脂质含量和肾功能的影响 -”在日本体质学会第 55 届全体会议上发表医学 (2001)

鈴木政登, 穂積典子: "糖尿病モデルOLETFラットに対する運動療法の影響-糖脂質代謝能,組織脂質含量および腎機能に及ぼす強度の影響-"第55回日本体力医学会総会にて発表. (2001)

Masato Suzuki、Noriko Hozumi：“运动疗法对糖尿病模型 OLETF 大鼠的影响 - 强度对糖脂代谢能力、组织脂质含量和肾功能的影响 -”在日本体能医学会第 55 届全体会议上发表（2001 年）。 ）

穂積典子, 鈴木政登, 他.: "糖尿病モデルラット(OLETF)における強制走運動が腎機能および組織形態学的所見におよぼす影響"第55回日本体力医学会総会にて発表. (2001)

Noriko Hozumi、Masato Suzuki 等人：“强迫跑步运动对糖尿病模型大鼠 (OLETF) 肾功能和组织形态学结果的影响”，在日本体能医学会第 55 届全体会议上发表（2001 年）。

穂積典子, 鈴木政登 他: "糖尿病モデルラット(OLETF)における強制走運動が腎機能および組織形態学的所見におよぼす影響"第55回日本体力医学会総会にて発表. (2001)

Noriko Hozumi、Masato Suzuki 等人：“强迫跑步运动对糖尿病模型大鼠 (OLETF) 肾功能和组织形态学结果的影响”，在日本体能医学会第 55 届全体会议上发表（2001 年）。

SUZUKI, M., KAWABE, N. and KIMURA, M.: "Effect of exercise therapy on OLETF rats as a model of type 2 diabetes mellitus. -Effects of execise intensity on glucose-fatty metabolish, fatty content in certain tissues and renal function- (in Japanese)."The 79t

SUZUKI, M.、KAWABE, N. 和 KIMURA, M.：“运动疗法对 OLETF 大鼠作为 2 型糖尿病模型的影响。-运动强度对葡萄糖-脂肪代谢、某些组织和肾脏中脂肪含量的影响