The mechanisms for exercise-induced proteinuria and useful determination method for renal function involved in exercise

运动性蛋白尿的机制及运动相关肾功能的有用测定方法

• 批准号: 62480437
• 负责人: SUZUKI Masato
• 金额: $ 4.29万
• 依托单位: The Jikeikai University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480437/
• 关键词: Exercise-induced proteinuria; Maximal exercise; Creatinine clearance; Renin.angiotensin system; Captopril; Microproteinuria; Renal blood flow; Radionuclide angiography; 運動性尿蛋白; 最大運動; クレアチニンクリアランス; 腎機能; 尿中アルブミン; β_2ミクログロブリン; フルマラソン; ^<99m>Tc

1. The relationship between exercise intensity and renal functionThe relationship between exercise intensity and renal function was examined in seven male volunteers using a treadmill. The grade of reduction in renal function was correlated with exercise intensity. The parameters most sensitive to changes in exercise intensity were urinary concentrating ability and Cl excretion.2. Using the radionuclide angiography method for measuring renal blood flow (RBF) following an exerciseA bolus of technetium-99m-phytate (^<99m> Tc-phytate, 92.5 MBq) was injected via a catheter into the brachial vein. The pool transit time (PTT) was calculated from the first derivative of the time-concentration flow curve in the left kidney following the injection of the bolus. The reciprocal number of the PTT was used as an index of blood flow in the kidney. The changes of RBF were examined in six male volunteers an exhaustive pedalling exercise. The mean RBF decreased by 58.4% immediately after, and by 20.7% at 60 min after the exercise. Significant high correlation was observed between the changes of RBF and Ccr.3. The mechanisms for exercise-induced proteinuriaOral administration of captopril (50 mg), which is angiotensin converting enzyme inhibitor, diminished increases in plasma concentration of angiotensin II (Ang II) immediately after exhaustive exercise in ten healthy male volunteers. However the urinary excretion of protein after the exercise was not inhibited by an administration of captopril.The result may suggest that Ang II is not so important for the exercise-induced proteinuria.

1.运动强度与肾功能的关系研究了7名男性志愿者在跑步机上运动时运动强度与肾功能的关系。肾功能下降的程度与运动强度相关。对运动强度变化最敏感的指标是尿浓缩能力和Cl排泄量.用放射性核素血管造影法测定运动后肾血流量（RBF）<99m>。根据推注后左肾中时间-浓度流量曲线的一阶导数计算合并液通过时间（PTT）。PTT的倒数被用作肾中血流的指数。对6名男性志愿者进行了力竭性蹬车运动，观察其径向基函数（RBF）的变化.运动后即刻平均RBF下降58.4%，运动后60 min平均RBF下降20.7%。RBF和Ccr的变化之间存在显著的高度相关性。10名健康男性志愿者口服血管紧张素转换酶抑制剂captopril（50 mg），可抑制力竭运动后即刻血浆血管紧张素II（angiotensin II，Ang II）浓度的升高。而服用卡托普利对运动后尿蛋白排泄无明显抑制作用，提示Ang Ⅱ在运动性蛋白尿中的作用并不重要。

项目成果

SUZUKI, Masato: "The mechanisms for exercise-induced proteinuria -Effects of captopril administration- (during arrange for contribution)" The Japanese Journal of Nephrology, 1990.

SUZUKI, Masato：“运动诱发蛋白尿的机制 - 卡托普利给药的影响 -（在安排投稿期间）” 日本肾脏病学杂志，1990 年。

SUZUKI, Masato: "Circadian variations of urinary excretions of microproteins and N-acetyl-beta-D-glucosaminidase (NAG) during the ordinary activity day." The Japanese Journal of Nephrology, 32(6) 1990.

SUZUKI, Masato：“在日常活动期间，微生物蛋白和 N-乙酰基-β-D-氨基葡萄糖苷酶 (NAG) 的尿液排泄量存在昼夜节律变化。”

SUZUKI,M,.et al.: "Using the radionuclide angiography method for measuring renal blood flow in healthy males following an exhaustive exercise." The Japanese Journal of Physiology.

SUZUKI,M,.et al.：“使用放射性核素血管造影方法测量健康男性在力竭运动后的肾血流量。”

鈴木政登,他: "運動性蛋白尿出現機序-captopril投与の影響-" 第67回日本生理学会大会発表予定.

铃木正人等人：“运动性蛋白尿的机制 - 卡托普利给药的效果” 计划在第 67 届日本生理学会年会上发表。

鈴木政登,井川幸雄: "平常生活時の微量蛋白尿および酵素Nーacetyl-β-D-glucosaminidase(NAG)尿中排泄の日内変動" 日本腎臓学会誌. 32巻6号. (1990)

铃木正人 (Masato Suzuki)、井川幸男 (Yukio Ikawa)：“追踪 N-乙酰基-β-D-氨基葡萄糖苷酶 (NAG) 尿排泄的蛋白尿和昼夜波动”，日本肾病学会杂志，第 32 期，第 6 期。 ）