The mechanisms for exercise-induced proteinuria and useful determination method for renal function involved in exercise

运动性蛋白尿的机制及运动相关肾功能的有用测定方法

• 批准号: 62480437
• 负责人: SUZUKI Masato
• 金额: $ 4.29万
• 依托单位: The Jikeikai University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480437/
• 关键词: Exercise-induced proteinuria; Maximal exercise; Creatinine clearance; Renin.angiotensin system; Captopril; Microproteinuria; Renal blood flow; Radionuclide angiography; 運動性尿蛋白; 最大運動; クレアチニンクリアランス; 腎機能; 尿中アルブミン; β_2ミクログロブリン; フルマラソン; ^<99m>Tc

1. The relationship between exercise intensity and renal functionThe relationship between exercise intensity and renal function was examined in seven male volunteers using a treadmill. The grade of reduction in renal function was correlated with exercise intensity. The parameters most sensitive to changes in exercise intensity were urinary concentrating ability and Cl excretion.2. Using the radionuclide angiography method for measuring renal blood flow (RBF) following an exerciseA bolus of technetium-99m-phytate (^<99m> Tc-phytate, 92.5 MBq) was injected via a catheter into the brachial vein. The pool transit time (PTT) was calculated from the first derivative of the time-concentration flow curve in the left kidney following the injection of the bolus. The reciprocal number of the PTT was used as an index of blood flow in the kidney. The changes of RBF were examined in six male volunteers an exhaustive pedalling exercise. The mean RBF decreased by 58.4% immediately after, and by 20.7% at 60 min after the exercise. Significant high correlation was observed between the changes of RBF and Ccr.3. The mechanisms for exercise-induced proteinuriaOral administration of captopril (50 mg), which is angiotensin converting enzyme inhibitor, diminished increases in plasma concentration of angiotensin II (Ang II) immediately after exhaustive exercise in ten healthy male volunteers. However the urinary excretion of protein after the exercise was not inhibited by an administration of captopril.The result may suggest that Ang II is not so important for the exercise-induced proteinuria.

1. 运动强度与肾功能的关系研究人员在7名使用跑步机的男性志愿者身上研究了运动强度与肾功能的关系。肾功能降低程度与运动强度相关。对运动强度变化最敏感的参数是尿浓缩能力和氯离子排泄。采用放射性核素血管造影术测量运动后肾血流量（RBF），通过导管向肱静脉注射锝-99m-植酸盐（^<99m> tc -植酸盐，92.5 MBq）。池传递时间（PTT）由注射后左肾时间-浓度流曲线的一阶导数计算。PTT的倒数数被用作肾脏血流的指标。研究人员对6名男性志愿者进行了详尽的蹬车运动，检测了RBF的变化。运动后立即平均RBF下降58.4%，运动后60分钟平均RBF下降20.7%。RBF与ccr变化呈显著高相关。运动诱导蛋白尿的机制：在10名健康男性志愿者中，口服卡托普利（50mg）（一种血管紧张素转换酶抑制剂）可在剧烈运动后立即降低血管紧张素II （Ang II）血浆浓度的增加。然而，运动后尿中蛋白质的排泄并没有被卡托普利抑制。这一结果可能提示Ang II对运动性蛋白尿的作用并不重要。

项目成果

SUZUKI, Masato: "The mechanisms for exercise-induced proteinuria -Effects of captopril administration- (during arrange for contribution)" The Japanese Journal of Nephrology, 1990.

SUZUKI, Masato：“运动诱发蛋白尿的机制 - 卡托普利给药的影响 -（在安排投稿期间）” 日本肾脏病学杂志，1990 年。

SUZUKI, Masato: "Circadian variations of urinary excretions of microproteins and N-acetyl-beta-D-glucosaminidase (NAG) during the ordinary activity day." The Japanese Journal of Nephrology, 32(6) 1990.

SUZUKI, Masato：“在日常活动期间，微生物蛋白和 N-乙酰基-β-D-氨基葡萄糖苷酶 (NAG) 的尿液排泄量存在昼夜节律变化。”

SUZUKI,M,.et al.: "Using the radionuclide angiography method for measuring renal blood flow in healthy males following an exhaustive exercise." The Japanese Journal of Physiology.

SUZUKI,M,.et al.：“使用放射性核素血管造影方法测量健康男性在力竭运动后的肾血流量。”

鈴木政登,他: "運動性蛋白尿出現機序-captopril投与の影響-" 第67回日本生理学会大会発表予定.

铃木正人等人：“运动性蛋白尿的机制 - 卡托普利给药的效果” 计划在第 67 届日本生理学会年会上发表。

鈴木政登,井川幸雄: "平常生活時の微量蛋白尿および酵素Nーacetyl-β-D-glucosaminidase(NAG)尿中排泄の日内変動" 日本腎臓学会誌. 32巻6号. (1990)

铃木正人 (Masato Suzuki)、井川幸男 (Yukio Ikawa)：“追踪 N-乙酰基-β-D-氨基葡萄糖苷酶 (NAG) 尿排泄的蛋白尿和昼夜波动”，日本肾病学会杂志，第 32 期，第 6 期。 ）