The Study on Cytokine Production of Helper T cell and its Therapeutic Effect in Allergic Rhinitis

应用流式细胞术检测变应性鼻炎患者外周血及腭扁桃体细胞内T细胞因子IL-4、TNF-α水平。此外，我们还研究了抗过敏药物托silat对Th2/Th1比率的治疗效果。托silat是已知的能使Th2/Th1失衡正常化的药物。结果显示鼻变态反应患者外周血单核细胞和扁桃体单核细胞中Th2/Th1的比率高于健康对照组，但差异无统计学意义。短期使用甲硅酸苏普司特对鼻变态反应患者外周血单核细胞Th2/Th1率无明确的治疗效果。但部分对托silast临床有效的患者在使用托silast后Th2/Th1比率降低。

By use of flow cytometry, we detected the intracellular cytokine of T cells, IL-4 and TNF-α, in peripheral blood and palatine tonsil from the patients with allergic rhinitis. In addition, we investigated the therapeutic effect to the rate of Th2/Th1 using anti-allergic agents, suplatast tosilat The suplatast tosilate is known that the agents which will normalize the Th2/Th1 unbalance.The results showed that the rate of Th2/Th1 from the patients with nasal allergy was higher than that from healthy control in peripheral mononuclear cells and tonsillar mononuclear cells, but there was no statistical significant.There was no definite therapeutic effect on the rate of Th2/Th1 in the peripheral mononuclear cells from the patients with nasal allergy after short-term using suplatast tosilate. But some cases who were clinically effective to the suplatast tosilate the rate of Th2/Th1 was reduced after using of suplatast tosilate.