Sublingual immunization-A new vaccination route for mucosa immunity and protection of upper respiratory infection

舌下免疫——粘膜免疫和上呼吸道感染防护的新接种途径

• 批准号: 20390443
• 负责人: KURONO Yuichi
• 金额: $ 12.48万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390443/
• 关键词: 粘膜免疫; 舌下免疫; ワクチン; IgA; ホスホリルコリン; 上気道感染; インフルエンザ菌; 肺炎球菌; 粘膜ワクチン; コレラキシン; 経鼻免疫; IgE抗体; 特異的IgA産生細胞; IgA腎症; 舌下ワクチン; コレラトキシン; PC特異的IgA産生細胞; PAF受容体; 口蓋扁桃; 抗体産生細胞

In order to investigate the effectiveness and safety of sublingual vaccine for protecting upper respiratory infection, phosphorylcholine (PC) was sublingually administered to mice and mucosal immune responses were examined. The results showed that sublingual immunization with PC induced mucosal and systemic immune responses as strong as intranasal immunization and increased bacterial clearance from nose, indicating the immune-protective effectiveness of sublingual vaccine. Further, it was demonstrated that sublingual vaccine reduced type I allergic reaction.

为探讨舌下含服疫苗预防上呼吸道感染的有效性和安全性，采用磷酸胆碱（PC）舌下含服小鼠，观察粘膜免疫应答。结果表明，PC舌下免疫可诱导与鼻内免疫同样强的粘膜和全身免疫应答，并能增加鼻内细菌清除率，表明PC舌下疫苗具有免疫保护作用。此外，证明舌下疫苗减少I型过敏反应。

项目成果

Sublingual immunization with phosphorylcholine has a potential of broad spectrum vaccine against upper airway infections.

舌下含磷酰胆碱免疫具有针对上呼吸道感染的广谱疫苗的潜力。

• 发表时间: 2009
• 作者: 田中紀充;黒野祐一;et al
• 通讯作者: et al

臨床粘膜免疫学-扁桃-

临床粘膜免疫学-扁桃体-

• 发表时间: 2010
• 作者: 清野宏(編集);黒野祐一(分担)
• 通讯作者: 黒野祐一(分担)

鼻咽腔関連リンパ組織

鼻咽相关淋巴组织

• 发表时间: 2010
• 期刊: 炎症と免疫 18(5)
• 作者: Nishio;et al.;Gen Ishikawa;黒野祐一
• 通讯作者: 黒野祐一

The role of vascular endothelial growth factor in pediatric otitis media with effusion.

• DOI: 10.1016/j.anl.2010.10.008
• 发表时间: 2011-06
• 期刊: Auris, nasus, larynx
• 作者: Kohsuke Sekiyama;J. Ohori;S. Matsune;Y. Kurono

Muosal immunology and its application for oreventingnupper respiratory infection.

粘膜免疫学及其在预防上呼吸道感染中的应用。

• 发表时间: 2010
• 作者: Y.Kurono