Sublingual immunization-A new vaccination route for mucosa immunity and protection of upper respiratory infection

为探讨舌下含服疫苗预防上呼吸道感染的有效性和安全性，采用磷酸胆碱（PC）舌下含服小鼠，观察粘膜免疫应答。结果表明，PC舌下免疫可诱导与鼻内免疫同样强的粘膜和全身免疫应答，并能增加鼻内细菌清除率，表明PC舌下疫苗具有免疫保护作用。此外，证明舌下疫苗减少I型过敏反应。

In order to investigate the effectiveness and safety of sublingual vaccine for protecting upper respiratory infection, phosphorylcholine (PC) was sublingually administered to mice and mucosal immune responses were examined. The results showed that sublingual immunization with PC induced mucosal and systemic immune responses as strong as intranasal immunization and increased bacterial clearance from nose, indicating the immune-protective effectiveness of sublingual vaccine. Further, it was demonstrated that sublingual vaccine reduced type I allergic reaction.