Basic research in excimer laser refractive surgery

准分子激光屈光手术基础研究

• 批准号: 11671737
• 负责人: MAEDA Naoyuki
• 金额: $ 1.86万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11671737/
• 关键词: Refractive surgery; visual function; optical property; corneal topography; wavefront analysis; videokeratoscope; wavefront sensor; biomechanics; エキシマレーザー; 角膜形状; PRK; CASIK; 収差; 不正乱視; UASIK; 波面収差; LASIK

This study was performed to establish the methods that can predict the corneal topographic change and the alteration of optical quality due to refractive surgery1) Correlation between corneal topography and visual functionLinear regression analyses were performed using corneal topography to predict the visual acuity and contrast sensitivity, and quantitative indices were obtained2) Relationship between biomechanics and corneal topography or visual functionDiurnal variations in vision and corneal topography following radial keratotomy were investigated, and we found out that mild hypoxia with soft contact lens can reduced this change. Animal model of scleral shortening procedure were developed using pig eyes, and the effect of surgery on the corneal topography were shown3) Factors that affected to the surgical effectsMultivariate analysis was performed to predict the surgical effects in astigmatic keratotomy, and results indicated preoperative amount of astigmatism and intraoperative misalignment were the important factors. The epidemiological study was performed to indicate the effects of factors such as sex and age on corneal topography4) Evaluation of optical quality using wavefront sensorTo evaluate the optical quality of the eye, wavefront sensor was developed. The relationship between higher-order astigmatism and amount of correction in LASIK, tear film, sclerosis of lens, effects of accommodation, and severity of keratoconus were clarified

进行了这项研究以建立可以预测角膜地形变化的方法，以及由于屈光外科手术而引起的光学质量的改变1）使用角膜敏锐度和对比度敏感性和定量界面的镜头和视觉效果，对角膜形态和视觉函数线性回归分析之间的相关性进行了构图和近视界面之间的构图和视觉效果，并进行了构型界限2）研究了角膜切开术，我们发现具有软接触透镜的轻度缺氧可以减少这种变化。使用Pig Eyes开发了巩膜缩短程序的动物模型，并显示了手术对角膜形态的影响。进行了流行病学研究，以指示性别和年龄等因素对角膜形态的影响4）使用波前Sensorto评估光学质量的评估，评估了眼睛的光学质量，波前传感器已开发出来。阐明了高阶散光与校正量之间的关系

项目成果

Maeda, Naoyuki: "LASIK : Fundamentals, Surgical Techniques, and Complications"Marcel Dekker, Inc. 13 (2002)

前田直之：“LASIK：基础知识、手术技术和并发症”Marcel Dekker, Inc. 13 (2002)

Tomidakoro,Atsuo et al: "Changes in anterior and posterior comed curvatunes in lceratoconus"Ophthalmology. 107. 1328-1332 (2000)

Tomidakoro，Atsuo 等人：“圆锥角锥型前、后角弯音的变化”眼科。

Tomoyuki Inoue, Naoyuki Maeda, Kaoru Sasaki, Hitoshi Watanabe, Yoshitsugu Inoue, Koji Nishida, Yumiko Inoue, Shuji Yamamoto, Yoshikazu Shimomura, Yasuo Tano: "Factors that influence the surgical effects of astigmatic keratotomy after cataract surgery"Opht

Tomoyuki Inoue、Naoyuki Maeda、Kaoru Sasaki、Hitoshi Watanabe、Yoshitsugu Inoue、Koji Nishida、Yumiko Inoue、Shuji Yamamoto、Yoshikazu Shimomura、Yasuo Tano：“影响白内障术后散光角膜切开术手术效果的因素”Opht

Koh S., Maeda N., et al.: "Effect of tear film break-up on higher-order aberrations measured with wavefront"Am J Ophthalmol. 134. 115-117 (2002)

Koh S.、Maeda N. 等人：“泪膜破裂对用波前测量的高阶像差的影响”Am J Ophamol。

Inoue, Tomoyuki, et al.: "Factors that influence the surgical effects of astigmatic keratotomy after cataract, surgery"Ophthalmology. 108. 1269-1274 (2001)

Inoue, Tomoyuki, et al.：“影响白内障术后散光角膜切开术手术效果的因素”眼科。