A study of neural mechanisms of the sleep apnea (A possible approach from dentistry)

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<1999-2000>In anesthetized rats, stimulation of the motor cortex A-area produced bruxism-like jaw movement. Bruxism-like jaw movement produced by A-area stimulation, however, did not induce the apnea. Parabrachial region in the brainstem induced the apnea.<2000-2001>The condition of sleep was reproduced in anesthetized rats. Electroencephalogram (EEG) was used to estimate the condition of sleep. When power spectrum of the EEG was analyzed, δ wave increased with he increase of concentration of halothane. The ratio of δ wave in the EEG under the concentration of 1.5 and 2.0 % was the same as compared with the ratio under the condition of sleep.<2001-2002>(1) Activation of the pontin locus coeruleus (LC) inhibited trigeminal sensorimotor function. This finding suggests that activation of the LC suppressed bruxism-like jaw movement during sleep.(2) During inhalation, excitation of trigeminal motoneurons synchronized with excitation of inspiratory neurons. This finding suggests the relationship between respiration movement and excitation of trigeminal motoneuron.