Quality Control of a Biodegradable Polymer using A Multivariable Controller, based on Metabolic Pathway Informaion
基于代谢途径信息,使用多变量控制器对可生物降解聚合物进行质量控制
基本信息
- 批准号:12650786
- 负责人:
- 金额:$ 2.3万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2000
- 资助国家:日本
- 起止时间:2000 至 2001
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Petroleum-based synthetic polymers are widespread used in a variety of plastic articles, which are usually disposable. From the view point of wastes problem, the most disadvantageous points of these synthetic polymers is their non-degradation characteristic in environment The aim of this study was development of control method of for quality control of, a biodegradable polymer, polyhydroxyalkanoates copolymer by means of controlling mole fraction of 3HV units in P(HB -co-HV).A novel mole fraction control was developed, based on metabolic reaction model and combined with the maximum production strategy at a given of fermentation time. The mole fraction of 3HV units successfully reached a desired value and the amount of P(HB-co-HV) was maximized at the final of cultivation time. A model predictive controller (MPC) was constructed in order to control alcohol concentration at a set point. Compared with the conventional PI controller and feedforward/feedback controller, it offers an significant improvement. As a result of developing the novel strategy, a new type of block P(HB-co-HV) was produced. The characterization was carried on using several techniques based on petrochemical-based plastic test methods. It was found that thermal properties such as melting temperature, glass transition temperature and enthalpy of fusion of the block polymer were different from those of random polymer. An enzymatic biodegradability of random and block polymers was compared in a wide rang of mole fraction of 3HV units. It was found that mole fraction of 3HV units affected on erosion rate due to an influence of the degree of crystallinity. The erosion rate of block polymer was higher than that of random polymer with the same mole fraction units.
石油基合成聚合物广泛用于各种塑料制品中,这些塑料制品通常是一次性的。从废物问题的角度来看,这些合成聚合物的最大缺点是它们在环境中的不可降解特性。本研究的目的是通过控制聚合物中3 HV单元的摩尔分数来控制可生物降解聚合物聚羟基脂肪酸酯共聚物的质量。基于代谢反应模型,结合最大产量控制策略,提出了一种新的摩尔分数控制方法。3 HV单元的摩尔分数成功地达到了所需的值,并且在培养时间的最后,P(HB-co-HV)的量达到最大。为了将酒精浓度控制在设定值,构建了模型预测控制器(MPC)。与传统的PI控制器和前馈/反馈控制器相比,该控制器具有明显的改善效果。作为开发新策略的结果,产生了新型嵌段P(HB-co-HV)。使用基于石化塑料测试方法的几种技术进行表征。结果表明,嵌段聚合物的熔融温度、玻璃化转变温度和熔融焓等热性能与无规聚合物不同。在较宽的3 HV单元摩尔分数范围内比较了无规和嵌段聚合物的酶降解性能。结果表明,由于结晶度的影响,3 HV单元的摩尔分数影响烧蚀速率。嵌段聚合物的冲蚀率高于相同摩尔分数单元的无规聚合物。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
S.Chanptrateep, K.Kikuya, H.Shimizu, S.Shioya: "Model Predictive Controller for Biodegradable poly hydroxyalkanoate production in Sed-batch culture"Journal of Biotechnology. (予定). (2002)
S.Champtraep、K.Kikuya、H.Shimizu、S.Shioya:“Sed 分批培养中可生物降解的聚羟基脂肪酸酯生产的模型预测控制器”生物技术杂志(计划)(2002 年)。
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- 影响因子:0
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S.Chanprateeg,N.Abe,H.Shimizu,T.Yamane,S.Shioya: "Multivariable Control of alcohol Concentrations in The Production of Polyhydroxyalkanoates(PHAs) by P.denitrificains"Biotechnology and Bioengineering. (予定). (2001)
S.Chanprateeg、N.Abe、H.Shimizu、T.Yamane、S.Shioya:“脱氮假单胞菌生产聚羟基脂肪酸酯 (PHA) 中酒精浓度的多变量控制”生物技术和生物工程(计划)。
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- 影响因子:0
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S.Chanprateep, N.Abe, H.Shimizu, T.Yamane, S.Shioya: "Multivariable Control of Alcohol Concentrations in the Production of Poly hydroxyalkanoates (PHAs) by P. denitrificans"Biotechnology and Bioengineering. 74(2). 116-124 (2001)
S.Chanprateep、N.Abe、H.Shimizu、T.Yamane、S.Shioya:“反硝化假单胞菌生产聚羟基脂肪酸酯 (PHA) 过程中酒精浓度的多变量控制”生物技术和生物工程。
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- 影响因子:0
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S.Chanpreteep, N.Abe, H.Shimizu, T.Yamano, S.Shioya: "Multivariable Control of Alcohol Concentrations in the Production of Polyhydroxyalkanoates (PHAS) by P. denitrificans"Biotechnology and Bioengineering. 74. 116-124 (2001)
S.Chanpreteep、N.Abe、H.Shimizu、T.Yamano、S.Shioya:“反硝化假单胞菌生产聚羟基脂肪酸酯 (PHAS) 过程中酒精浓度的多变量控制”生物技术和生物工程。
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- 影响因子:0
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S.Chanprateep, K.Kikuya, H.Shimizu, S.Shioya: "Model Predictive Controller for Biodegradable Poly Rydroxyalkandetes Production in Fed-Batch Culture"J. Biotechnology. (予定). (2002)
S.Chanprateep、K.Kikuya、H.Shimizu、S.Shioya:“补料分批培养中可生物降解的聚羟基烷酸酯的模型预测控制器”(计划)。
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SHIMIZU Hiroshi其他文献
Aftershock Activity of the 2015 <i>M</i> 7.1 Earthquake and Back-Arc Rifting in the Northern Okinawa Trough
2015年7.1级地震余震活动及冲绳北部海槽弧后裂谷
- DOI:
10.4294/zisin.2021-12 - 发表时间:
2022 - 期刊:
- 影响因子:0
- 作者:
YANAGIDA Hirotsugu;NAKATANI Yukihiro;YAKIWARA Hiroshi;HIRANO Shuichiro;KOBAYASHI Reiji;YAMASHITA Yusuke;MATSUSHIMA Takeshi;SHIMIZU Hiroshi;UCHIDA Kazunari;UMAKOSHI Kodo;YAGI Mitsuharu;MORII Yasuhiro;NAKAHIGASHI Kazuo;SHINOHARA Masanao - 通讯作者:
SHINOHARA Masanao
Castable polymer-infiltrated ceramic network composite for training model tooth with compatible machinability to human enamel
用于训练模型牙齿的可浇铸聚合物渗透陶瓷网络复合材料,具有与人类牙釉质兼容的机械加工性能
- DOI:
10.4012/dmj.2021-299 - 发表时间:
2022 - 期刊:
- 影响因子:2.5
- 作者:
TOKUNAGA Jumpei;IKEDA Hiroshi;NAGAMATSU Yuki;AWANO Shuji;SHIMIZU Hiroshi - 通讯作者:
SHIMIZU Hiroshi
Study of application system of digested slurry after anaerobic digestion as liquid fertilizer
厌氧消化后消化液作为液体肥料施用体系的研究
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
OHDOI Katsuaki;RYU Chanseok;IIDA Michihisa;SHIMIZU Hiroshi;NAKAZIMA Hiroshi;MIYASAKA Turo - 通讯作者:
MIYASAKA Turo
SHIMIZU Hiroshi的其他文献
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{{ truncateString('SHIMIZU Hiroshi', 18)}}的其他基金
携帯型脳波計による小児睡眠評価法の検証と検査実施手法の確立
便携式脑电图儿童睡眠评估方法验证及测试实施方法建立
- 批准号:
19H00465 - 财政年份:2019
- 资助金额:
$ 2.3万 - 项目类别:
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Development of Simulation System of Cancer Metabolism
癌症代谢模拟系统的开发
- 批准号:
17K19012 - 财政年份:2017
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$ 2.3万 - 项目类别:
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General study on the 2016 Kumamoto earthquake and related activities
2016年熊本地震及相关活动的综合研究
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16H06298 - 财政年份:2016
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Grant-in-Aid for Special Purposes
Identification of Limiting Step and Optimization of Metabolism based on Analysis of Dynamic Behaviors of Multilayers Omics Data
基于多层组学数据动态行为分析的限制步骤识别和代谢优化
- 批准号:
16H04576 - 财政年份:2016
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$ 2.3万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
A study on the formation of injunctive norm by normative propagation
规范传播形成禁令性规范的研究
- 批准号:
15K17250 - 财政年份:2015
- 资助金额:
$ 2.3万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Modulation of skin microbiota through basememt membrane
通过基底膜调节皮肤微生物群
- 批准号:
25670494 - 财政年份:2013
- 资助金额:
$ 2.3万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Investigation of hematopoietic stem cell transplantation for epidermolysis bullosa
造血干细胞移植治疗大疱性表皮松解症的探讨
- 批准号:
24249062 - 财政年份:2012
- 资助金额:
$ 2.3万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Generation of dominant dystrophic epidermolysis bullosa model mice using humanized COL7 mice
使用人源化 COL7 小鼠产生显性营养不良性大疱性表皮松解症模型小鼠
- 批准号:
24659516 - 财政年份:2012
- 资助金额:
$ 2.3万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
a study for the emergence of injunctive norms.
对禁令性规范出现的研究。
- 批准号:
24730509 - 财政年份:2012
- 资助金额:
$ 2.3万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Development of artificial pollination system using air vibration
利用空气振动的人工授粉系统的开发
- 批准号:
23658201 - 财政年份:2011
- 资助金额:
$ 2.3万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
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