Development of Diopside-BMP compound implant for maxillofacial reconstraction cases

用于颌面重建病例的透辉石-BMP复合种植体的开发

• 批准号: 12671966
• 负责人: YAJIMA Yasutomo
• 金额: $ 0.64万
• 依托单位: TOKYO DENTAL COLLEGE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671966/
• 关键词: diopside; rhBMP-2; implant; hydroxyapatite; maxillofacial reconstraction; rhBMP2; diopside; diopside-BMP複合インプラント

Recovery of a chewing function for the case that jaw or a face was removed surgically by a malignant tumor is a theme to be very important from a respect of QOL. We have planed recovery of a function using dental implant for these cases. However, it is known that the success rate is low in the existing implant material so that it is used for a jaw bone of no good condition. Thus we pushed forward this study aiming at development of Diopside-BMP compound implant.At frist using adult dogs, dental implants were placed into the mandibles of no good condition (for a wide bone defect, vascularized bone graft group and free bone graft group). As a result of having observed it about osteogenesis process around implants, in the vascularized bone graft group belonging to, build-up of new bone was seen from early stage, and the implant showed integration with a bone in authenticity. However, absorption of a bone condinued in free bone graft group, and remodeling were recognized from out side of cortical bon, new bone formation around implants could be recognized after long term. Next, in the experimental study of rabbits, the carrier experiment of rhBMP-2 was investigated. As a result, certain bone formation was provided early, and it was able to be recovered in original configuration mandibles by using atelocollagen sponge and a poly lactic acid-co-glycolic acid membrane.Furthermore, we developed the implant which coating turned a HA film of about 1um into titanium core materials circumference. These were placed into the implant bony sockets that were formed by excess, and it became clear to integrate with bone early in comparison with titanium.

从QOL的角度来看，下颌或面部因恶性肿瘤而被手术切除的情况下的咀嚼功能的恢复是非常重要的主题。对于这些病例，我们计划使用种植牙来恢复功能。然而，众所周知，现有的植入材料成功率较低，因此用于状况不佳的颌骨。因此我们推进了这项旨在开发透辉石-BMP复合种植体的研究。首先使用成年犬，将牙种植体植入到状况不佳的下颌骨中（对于宽骨缺损、血管化骨移植组和游离骨移植组）。对种植体周围的成骨过程进行观察的结果是，在所属的血管化骨移植组中，从早期就看到了新骨的形成，并且种植体显示出与骨的真实融合。然而，在游离骨移植组中，骨的吸收仍在继续，并且从皮质骨外侧可以看到重塑，长期后可以看到种植体周围的新骨形成。接下来，在兔子的实验研究中，研究了rhBMP-2的载体实验。结果，早期提供了一定的骨形成，并且通过使用去端肽胶原海绵和聚乳酸-乙醇酸共聚物膜，能够将其恢复到原始形态的下颌骨。此外，我们开发了将约1um的HA膜涂层转化为钛芯材料圆周的种植体。这些被放置在由多余部分形成的种植体骨槽中，与钛相比，很明显可以更早地与骨结合。

项目成果

矢島安朝: "口腔悪性腫瘍切除後に用いられた骨内インプラントの長期治療成績"歯界展望. 96. 100-101 (2000)

Yasutomo Yajima：“口腔恶性肿瘤切除后使用的骨内种植体的长期治疗结果”Dental Perspectives 96. 100-101 (2000)。

山内智博: "超薄膜HAコーティングインプラントの骨形成過程に関する実験的研究"日本顎顔面インプラント学会誌. 1(発行予定). (2002)

Tomohiro Yamauchi：“超薄HA涂层种植体骨形成过程的实验研究”日本颌面种植学会杂志1（待出版）。

Furuya Y: "Experimental studies on the osteogenesis process around dental implants in vascularized bone replantations"Japanese Journal of Oral and Maxillofacial Surgery. 48(in press). (2002)

Furuya Y：“血管化骨再植中牙种植体周围成骨过程的实验研究”日本口腔颌面外科杂志。

矢島安朝,野間弘康: "口腔悪性腫瘍切除後に用いられた骨内インプラントの長期治療成績"歯界展望. Vol.96 No.6. 1336-1337 (2000)

Yasutomo Yajima、Hiroyasu Noma：“口腔恶性肿瘤切除术后使用的骨内种植体的长期治疗结果”Dental Perspectives Vol.96 No.6 (2000)。

Yajima Y: "Long-term results of endsteal implants used for restortion of oral function after oncologic surgery"Dental Outlook. 96. 100-101 (2000)

Yajima Y：“用于肿瘤手术后口腔功能恢复的骨内种植体的长期结果”《牙科展望》。