RHBMP-2 EFFECT ON BMD IN AN OSTEOPOROTIC BABOON VERTEBRAE + PROXIMAL FEMUR

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to evaluate whether rhBMP-2, a bone inducing agent, is capable of improving bone mass, thereby reducing bone fragility and fracture risk, in vertebral bodies and femurs of osteoporotic baboons. We propose injecting the animals with a solid POE pellet containing rhBMP-2. The surgical procedure would be very similar to a vertebroplasty surgery, where a cannula and a fluoroscope would be used to identify the pedicle on the vertebral body, the pedicle would then be pierced, and the POE/rhBMP-2 pellet injected. The entrance defect would be sealed with bone wax. The same approach can be utilized in the proximal femur of the primate. As a result of the study we would expect to observe an increased bone mass of the vertebral body and the proximal femur. DEXA, microCT and histology will be the parameters that will be examined per each treatment group. This project could address the growing need for a therapy that could prevent osteoporotic factures in high risk individuals. Current systemic therapies aimed at increasing bone mineral density do not eliminate the estimated 750,000 vertebral factures that occur as a result of osteoporosis. Bone morphogenetic proteins such as rhBMP-2 have a known record of local bone formation and we hypothesize that local delivery of this protein will be successful in rapidly enhancing local bone structure.