Investigation of flow-mediated vasodilation in female athletes with exercise-associated amenorrhea

运动相关闭经女运动员血流介导的血管舒张研究

基本信息

  • 批准号:
    13670771
  • 负责人:
  • 金额:
    $ 2.62万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2001
  • 资助国家:
    日本
  • 起止时间:
    2001 至 2002
  • 项目状态:
    已结题

项目摘要

Background Exercise-associated amenorrhea (EAA) is frequently observed in highly trained female athletes associated with a hypoestrogenic state. Vascular endothelial function is modulated during the menstrual cycle. The purpose of the present study was to investigate vascular endothelial function in highly trained female athletes with EAA.Methods and Results The study subjects consisted of 26 female volleyball players, who had a regular menstrual cycle (regular group, n=15) and EAA (EAA group, n=11). Vasodilatory responses of the brachial artery were evaluated by measuring endothelium-dependent flow-mediated vasodilation (FMD) and glyceryltrinitrate (an endothelium-independent dilator)-induced vasodilation using high-resolution ultrasonography. Plasma levels of estradiol and progesterone were measured in all the subjects. In the regular group, all measurements were performed at 12 to 14 days after the first day of the last menstrual cycle. Plasma estradiol levels were significantly lower in the EAA group than in the regular group (p<0.05). Plasma progesterone levels did not differ between the two groups. The regular and EAA groups did not differ in terms of arterial diameter and blood flow at baseline, nor in blood flow during hyperemia. FMD was significantly smaller in the EAA group than in the regular group (p<0.05). Glyceryltrinitrate-induced vasodilation did not differ between the groups. FMD significantly correlated with plasma estradiol levels (r=0.41, p<0.05).Conclusions Endothelium-dependent vasodilation was impaired in highly trained female volleyball players with EAA associated with a hypoestrogenic state. Thus, the detrimental effects of vigorous exercise training on vascular endothelial function may have important clinical implications for the health of female athletes.
运动相关性闭经(EAA)常发生在高强度训练的女性运动员中,与雌激素水平低下有关。血管内皮功能在月经周期中受到调节。本研究的目的是探讨血管内皮功能在高训练的女性运动员EAA。方法和结果研究对象包括26名女子排球运动员,谁有规律的月经周期(定期组,n=15)和EAA(EAA组,n=11)。通过使用高分辨率超声测量内皮依赖性血流介导的血管舒张(FMD)和硝酸甘油(一种内皮非依赖性扩张剂)诱导的血管舒张来评价肱动脉的血管舒张反应。测定所有受试者的血浆雌二醇和孕酮水平。在常规组中,所有测量均在末次月经周期第一天后12至14天进行。EAA组血浆雌二醇水平显著低于常规组(p<0.05)。两组间血浆孕酮水平无差异。常规组和EAA组在基线时的动脉直径和血流量方面没有差异,充血时的血流量也没有差异。EAA组FMD明显小于常规组(p<0.05)。硝酸甘油诱导的血管舒张在两组之间没有差异。FMD与血浆雌二醇水平呈显著正相关(r= 0.41,p <0.05)。结论高强度训练的女排运动员EAA患者存在低雌激素状态,其内皮依赖性血管舒张功能受损。因此,剧烈运动训练对血管内皮功能的不利影响可能对女性运动员的健康具有重要的临床意义。

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
池田 久雄: "喫煙と血小板"血小板生物学,メディカルレビュー社. (印刷中).
池田久男:《吸烟与血小板》血小板生物学,Medical Review Co., Ltd(出版中)。
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    0
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Noriko Yoshida: "Exercise Therapy of Hypertension, Rinsyou Kouketuatu"Asakura Syoten. 139-146 (2002)
吉田纪子:“高血压的运动疗法,Rinsyou Kouketuatu”Asakura Syoten。
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    0
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Hisao Ikeda: "Smoking and Platelet, Biology of Platelet"Medical Review, (in press).
Hisao Ikeda:“吸烟与血小板,血小板生物学”医学评论,(正在出版)。
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    0
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吉田 典子: "運動負荷試験:最近の話題"Annual Review循環器2001. 中外医学社. 155-160 (2001)
Noriko Yoshida:“运动压力测试:最近的主题”年度回顾心脏病学 2001。Chugai Igakusha 155-160 (2001)。
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    0
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  • 通讯作者:
吉田 典子: "運動指導"臨床高血圧 朝倉書店. 139-146 (2002)
吉田纪子:《运动指导》临床高血压朝仓书店139-146(2002)。
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    0
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YOSHIDA Noriko其他文献

YOSHIDA Noriko的其他文献

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{{ truncateString('YOSHIDA Noriko', 18)}}的其他基金

Development of Resistanse Training Program for Privention of Cardiovascular Disease
预防心血管疾病的抵抗力训练计划的制定
  • 批准号:
    24500879
  • 财政年份:
    2012
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Baudelaire and Zola: Succession and transformation ofthe concept of "La modernite" in Art and Literature
波德莱尔与左拉:艺术与文学中“现代派”概念的继承与转变
  • 批准号:
    21520328
  • 财政年份:
    2009
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A condition of the barrier-free maintenance in the castle Based on a difference of the publicity of welfare of handicapped persons and the cultural properties protection
基于残疾人福利宣传与文化遗产保护差异的古堡无障碍维护状况
  • 批准号:
    21730457
  • 财政年份:
    2009
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Linguistic Geography Research through the reports by the National Language Survey Committee in Meiji period,"The Linguistic Atlas of Japan", and "The Grammar Atlas of Japanese Dialects"
通过明治时期国家语言调查委员会的报告、《日本语言图集》、《日语方言语法图集》进行语言地理学研究
  • 批准号:
    20520430
  • 财政年份:
    2008
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Effects of Dietary Intake Modification and Physical Activity on Oxidative Stress in Patients With Life-style Related Disease
膳食摄入量调整和体力活动对生活方式相关疾病患者氧化应激的影响
  • 批准号:
    20500637
  • 财政年份:
    2008
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Advertisement, city and industry : French posters of the Art Deco period and the theory of ≪ advertising art ≫
广告、城市与工业:装饰艺术时期的法国海报与《广告艺术》理论
  • 批准号:
    19820026
  • 财政年份:
    2007
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Grant-in-Aid for Young Scientists (Start-up)
The effects of exercise on oxidative stress in patients with life-style related diseases
运动对生活方式相关疾病患者氧化应激的影响
  • 批准号:
    18500561
  • 财政年份:
    2006
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Study of Zola's novels, art criticism and French paintings from the 1860s-1880s : Modern Paris and the artistic modernism
左拉小说、艺术评论和1860-1880年代法国绘画研究:现代巴黎和艺术现代主义
  • 批准号:
    16520152
  • 财政年份:
    2004
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Relation of Exercise Induces Amenorrhea and Endothelial Function-The Follow up Study
运动引起闭经与内皮功能关系的跟踪研究
  • 批准号:
    15500466
  • 财政年份:
    2003
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Study on the Formative Era of Modem Society in France - Women's Situation in Naturalist Novels
法国近代社会形成时期研究——自然主义小说中的女性处境
  • 批准号:
    11610517
  • 财政年份:
    1999
  • 资助金额:
    $ 2.62万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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Post exercise hypotenstion in female athaltes
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