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The effects of exercise on oxidative stress in patients with life-style related diseases

运动对生活方式相关疾病患者氧化应激的影响

基本信息

批准号：
18500561
负责人：
YOSHIDA Noriko
金额：
$ 2.38万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500561/
关键词：
oxidative stress life-style related disease exercise physical training 運動トレーニング運動強度

项目摘要

Objective: The effects of exercise training on oxidative stress were examined in patients with life-style related diseases. Method: Subjects were 29 patients with life-style related diseases those were hypertension, diabetes or hyperlipidemia. 1) The acute effect of one exercise session: Patients took fixed load (50% estimated VO2 max) exercise by bicycle ergometor for 30 minutes. Blood samplings were performed at rest, the end of exercise session during exercise, 7 minutes and 15 minutes after exercise. Free radical analytical system (Diacron Co. Italy) was used to measure the reactive oxygen metabolites (ROMs) and the biological antioxidant potential (BAP). ROMs/BAP was defined as index of oxidative stress. 2) The effect of exercise training: patients performed exercise (50% estimated VO2 max) training by bicycle ergometor more than three times per week for 12 weeks. The duration time of one exercise session was 30 minutes or more. Result: there were no significant changes in ROMs/BAP during and after fixed load (50% estimated VO2 max) exercise. After 12 weeks exercise, although ROMs unchanged, BAP increased at rest, during exercise and after exercise. Accordingly, ROMs/BAP decreased significantly at rest, during exercise and after exercise.Conclusion : patients with life-style related diseases could perform 50% estimated VO2 max exercise without increased oxidative stress. Aerobic exercise training may decrease oxidative stress in patients with life-style related diseases.

目的：探讨运动训练对生活方式相关疾病患者氧化应激的影响。方法：以29例高血压、糖尿病、高脂血症等生活方式相关疾病患者为研究对象。1)一次运动的急性效应：患者在自行车功率计上进行固定负荷（50%估计的最大摄氧量）运动30分钟。在休息时、运动期间运动结束时、运动后7分钟和15分钟进行血液采样。自由基分析系统（Diacron Co.意大利）用于测定活性氧代谢产物（ROM）和生物抗氧化潜力（BAP）。以ROMs/BAP为氧化应激指标。2)运动训练的效果：患者每周进行3次以上的自行车功量计运动（50%估计的VO 2 max）训练，持续12周。每次运动的持续时间为30分钟或更长。结果：固定负荷（50%VO2max）运动前后ROM/BAP无明显变化。运动12周后，虽然ROM不变，但BAP在休息时、运动中和运动后均增加。因此，ROM/BAP在休息时，在运动中和运动后显着降低。结论：生活方式相关疾病的患者可以进行50%的估计VO 2最大运动，而不增加氧化应激。有氧运动训练可以降低生活方式相关疾病患者的氧化应激。