A new thrapy for severe acute pancreatitis by regulating the cannabinoid

通过调节大麻素治疗重症急性胰腺炎的新疗法

基本信息

  • 批准号:
    13671276
  • 负责人:
  • 金额:
    $ 0.83万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2001
  • 资助国家:
    日本
  • 起止时间:
    2001 至 2002
  • 项目状态:
    已结题

项目摘要

Cannabinoids are the pharmacologically essential components of marihuana. Anandamide (ANA) is one of the cannabinoids and it has recently become clear that anandamide is one of the mediators in septic shock. The pathogenesis of acute pancreatitis is not clearly understood and whether there is a relationship between acute pancreatitis and cannabinoids is unknown. Therefore, we aimed to clarify the relationship between acute pancreatitis and cannabinoids and to find a new therapy to regulate the cannabinoids in acute pancreatitis. Rats were injected with cerulein intravenously to induce mild edematous pancreatitis and were injected with 5% sodium taurochorate to the bilio-pancreatic duct to induce severe necrotizing pancreatitis. After the induction of pancreatitis, blood was collected to measure the plasma anandamide value by the LC/MS/MS method. Kidneys were stained immunohistochemically to evaluate the appearance of the cannabinoid receptor 1 (CBI receptor). Finally, rats were injected with the antagonist of the CB1 receptor (SR141716A) after the induction of severe acute pancreatitis to clarify the role of cannabinoids in the pathogenesis of acute pancreatitis. After the induction of acute pancreatitis, the values of the anandamide increased and the value of severe pancreatitis was significantly higher than that of mild pancreatitis. The appearance of CBI rceptors in the glomerulus of the kidney was elevatd only after the induction of severe acute pancreatitis. The local inflammatory changes in the pancreas were not different regardless of the injection of SR141716A. However, the mortality rate was significantly reduce by the injection of SRI41716A. These findings indicate that cannabinoids have an important roll in the deterioration of acute pancreatitis and that the regulation of cannabinoids could be a new therapy for severe acute pancreatitis.
大麻素是大麻的主要成分。大麻素(ANA)是大麻素之一,最近已经清楚大麻素是感染性休克的介质之一。急性胰腺炎的发病机制尚不清楚,急性胰腺炎与大麻素之间是否存在关系尚不清楚。因此,我们的目的是阐明急性胰腺炎与大麻素的关系,并找到一种新的治疗方法来调节大麻素在急性胰腺炎。用蛙皮素静脉注射诱发大鼠轻度水肿性胰腺炎,用5%牛磺胆酸钠胰管注射诱发大鼠重度坏死性胰腺炎。诱导胰腺炎后,收集血液,通过LC/MS/MS方法测量血浆花生四烯酸含量。肾脏进行化学染色,以评价大麻素受体1(CBI受体)的外观。最后,大鼠注射CB 1受体拮抗剂(SR 141716 A)后,诱导重症急性胰腺炎,以阐明大麻素在急性胰腺炎的发病机制中的作用。诱导急性胰腺炎后,花生四烯酸含量升高,重症胰腺炎明显高于轻型胰腺炎。CBI受体仅在重症急性胰腺炎诱发后才在肾小球内出现。无论注射SR 141716 A与否,胰腺中的局部炎症变化均无差异。然而,通过注射SRI 41716 A,死亡率显著降低。这些发现表明,大麻素在急性胰腺炎的恶化中具有重要作用,大麻素的调节可能是重症急性胰腺炎的新疗法。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Yamauchi J: "Cytokine modulation in acute pacretitis"J Hepatobiliary Pancreat Surg. 8. 195-203 (2001)
Yamauchi J:“急性胰腺炎的细胞因子调节”J Hepatobiliary Pancreat Surg。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Mikami,Y: "Do peritonaeal macrophages play an essential role in the Proguress in of acute pancreatitis in rat?"Pancreas. in press. (2003)
Mikami,Y:“腹膜巨噬细胞在大鼠急性胰腺炎的进展中发挥重要作用吗?”胰腺。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Mikami,Y: "Relationship of intiltration dynamics and cytokine production With sever oh illness"Surgery. 132. 86-92 (2002)
Mikami,Y:“渗透动力学和细胞因子产生与严重疾病的关系”手术。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Yamauchi,J: "Cytokine modulation in acute pacreatitis"J Hepatobiliary Paucreat Surg. 8. 195-203 (2001)
Yamauchi,J:“急性胰腺炎的细胞因子调节”J Hepatobiliary Paucreat Surg。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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TAKEDA Kazunori其他文献

TAKEDA Kazunori的其他文献

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{{ truncateString('TAKEDA Kazunori', 18)}}的其他基金

Realization of Neuro-Diversity by Optimisation of Reasonable Accommodation and Support Model in University
优化大学合理住宿与支持模式实现神经多样性
  • 批准号:
    18H03653
  • 财政年份:
    2018
  • 资助金额:
    $ 0.83万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Interdisciplinary research of reasonable accommodation on academic support for students with disabilities
残疾学生学术支持合理便利的跨学科研究
  • 批准号:
    26245086
  • 财政年份:
    2014
  • 资助金额:
    $ 0.83万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
A study on evaluation of mental stress using non-invasive physyological measurement in psychological support of hospitalized children
无创生理测量评估住院儿童心理支持中的精神压力研究
  • 批准号:
    23531276
  • 财政年份:
    2011
  • 资助金额:
    $ 0.83万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The evaluation of distress using biomarkers in children with health impairment
使用生物标志物评估健康受损儿童的痛苦
  • 批准号:
    20530875
  • 财政年份:
    2008
  • 资助金额:
    $ 0.83万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Research on emotional monitoring in children with severe motor and intellectual disabilities
严重运动和智力障碍儿童情绪监测研究
  • 批准号:
    17530684
  • 财政年份:
    2005
  • 资助金额:
    $ 0.83万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
PATHOGENESIS OF PANCREATIC SOTONE : STUDIES ON THE ORGANIC MATRIX OF HUMAN PANCREATIC STONES.
胰腺结石的发病机制:人类胰腺结石有机基质的研究。
  • 批准号:
    05807111
  • 财政年份:
    1993
  • 资助金额:
    $ 0.83万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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