A study on evaluation of mental stress using non-invasive physyological measurement in psychological support of hospitalized children

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In this study, we intended to clarify the utility of salivary biomarkerthat are non-invasive and subjective physiological method.Results are as follows.1. Among children hospitalized for a long time by the treatment of childhood cancer, after the artificial activity (ex. painting), salivary amylase activity, an indicator of acute stress, were significantly decreased.2. Among children hospitalized for a long time by the treatment of childhood cancer, abnormalities were observed in the pattern of diurnal variation of salivary amylase activity level.From the above, salivary biomarkers (ex. amylase activity) are useful for evaluation of negative stress in long-term hospitalized children, such as childhood cancer.