Physical Property of the cupula as a mechanoreceptor

杯托作为机械感受器的物理特性

• 批准号: 13671804
• 负责人: SUZUKI Mamoru
• 金额: $ 0.38万
• 依托单位: Tokyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671804/
• 关键词: cupula; semicircular canal; sensory cilia; ampulla; endolymph; canal plugging; dissection microscope; 実体顕微鏡; 膜迷路

Physical property of the semicircular canal cupula was studied using bull frog's labyrinth. The membranous labyrinth was en bloc removed and a smallhole was made at the crus commune. India ink was carefully injected through this hole in order to stain the posterior canal cupula surface. A partof the canal was depressed using fine needle and the amount the cupula shift was measured. The cupula moved as a diaphragm with depression of20 M m and as a swing door with 40 fj. m. The effect of canal plugging was studied using isolated semicircular canal with one canal end sutured. Canal plugging resulted in greater ampujlary nerve response, indicating the endolymphatic volume change was enhanced b;y plugging. The attachment between the cupula and the ampullary wall was studied usingIndia ink injected around the cupula. With intense endolymphatic volume shift, the ink passed through the cupula surface, indicating rather weak attachment between the cupula and the ampullary wall. This loose attachment probably contributes to prevention of cupula dislocation when excessive endolymphatic stimulus is given.

用牛蛙迷路法研究了半规管壶腹的物理性质。将膜迷路整块切除，并在迷路总处开一个小孔。通过该孔小心地注入印度墨水，以染色后髓腔杯表面。用细针压迫部分髓腔，测量壶腹移位量。吸盘的运动方式为20 M m的隔膜运动和40 fj的摆门运动。M.用单根半规管端缝合的方法观察半规管封闭的效果。管堵塞导致更大的Amphujlary神经反应，表明B;y堵塞增强了内淋巴体积的变化。在壶腹周围注入墨汁，观察壶腹与壶腹壁的附着情况。墨汁通过壶腹表面，壶腹与壶腹壁之间的附着较弱，并伴有内淋巴容积的强烈移位。这种松散的附着可能有助于防止过度的内淋巴刺激时，髋臼杯脱位。

项目成果

Koji Otsuka: "Model of benign paroxysmal positional vertigo mechanism using the whole membranous labyrinth"Acta Otolaryngologica. (in press).

Koji Otsuka：“使用整个膜迷路的良性阵发性位置性眩晕机制模型”耳鼻喉科学报。

鈴木 衞: "眼振の推移からみた半規管遮断術の効果"耳鼻咽喉科臨床. 95. 1017-1020 (2002)

Akira Suzuki：“从眼球震颤过程的角度观察半规管阻塞的影响”耳鼻喉科临床。 95. 1017-1020 (2002)

Mamoru Suzuki, et al: "The effect of canal plugging evaluatedbypositional nystagmus"Practica Otologica. 95-10. 1017-1020 (2002)

Mamoru Suzuki 等人：“通过位置性眼球震颤评估耳道堵塞的效果”Practica Otologica。

Koji Otsuka, Mamoru Suzuki, et al: "Model of benign paroxysmal positional vertigo mechanism using the whole membranous labyrinth"Acta Otolaryngologica. in press.

Koji Otsuka、Mamoru Suzuki 等人：“使用整个膜迷路的良性阵发性位置性眩晕机制模型”Acta Otolaryngologica。

鈴木衛: "眼振の推移からみた半規管遮断術の効果"耳鼻咽喉科臨床. 95. 1017-1020 (2002)

Mamoru Suzuki：“从眼球震颤进展角度观察半规管阻塞的影响”耳鼻喉科临床。 95. 1017-1020 (2002)