RELTION BETWEEN PERIODONTAL STATUS AND CARDIOVASCULAR RISK FACTORS

牙周状况与心血管危险因素之间的关系

• 批准号: 13671995
• 负责人: TAMAZAWA Kaoru
• 金额: $ 2.56万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671995/
• 关键词: Periodontal disease; Cardiovascular disease; Risk Factor; Hypertension; Smoking; Hyperlipidemia; Bleeding on probing; Porphyromonas gingivalis; 心疾患

Hypertension (HT), hyperlipidemia (HP) and smoking habit (SH) are major risk factors for cardiovascular disease (CVD). The purpose of this study is to investigate the association between periodontal status (PHS) and major risk factors for CVD. The subjects are patients who undergo treatment for a HT in an affiliated hospital of our university. The following parameters were examined. Examination of CVD : age, gender, family history, medical history, history of smoking, lifestyle, blood pressure (SBP,DBP,MBP,PP), pulse wave velocity (PWV), blood examination (TCH,HDL,LDL,TG,BUN,UA,Cr,FBS,HbA1c), obesity index, medications. Examination of PHS : probing depth (PD), bleeding on probing (BOP), GI, plaque index, coated tongue score, breath odor. Examination of bacteria : saliva, sub-gingival plaque.<Results>The subjects were divided into 2 groups : the risk group with a HT and the high-risk group with a HT and a HP or with a HT and a SH. There were significant differences in BOP (p<0.05) and GI (p<0.01) between high risk group with a HT and a SH (n=32) and the risk group (n=39). This suggested that there may be associated with PHS arid CVD. Porphyromoncis gingivalis (Pg), is putative periodontal pathogens, cannot becultivated in all of 142 samples. On the other hand, Pg prevalence detected by real time PCR was 90 % (9samples out of 10). PCR methods have been used for detection of microorganisms that cannot be cultivated but these methods have given cross-reactions with related organisms.In the future, we should collect more data to clarify correlation to PHS and CVD used by the method to accurately detect species in mixed bacteria populations

高血压（HT）、高脂血症（HP）和吸烟习惯（SH）是心血管疾病（CVD）的主要危险因素。本研究的目的是调查牙周状况（PHS）和CVD的主要危险因素之间的关系。受试者是在我校附属医院接受HT治疗的患者。检查了以下参数。CVD检查：年龄、性别、家族史、病史、吸烟史、生活方式、血压（SBP、DBP、MBP、PP）、脉搏波速度（PWV）、血液检查（TCH、HDL、LDL、TG、BUN、UA、Cr、FBS、HbA 1c）、肥胖指数、药物治疗。PHS检查：探诊深度（PD）、探诊出血（BOP）、GI、菌斑指数、舌苔评分、口臭。细菌检查：唾液、龈下菌斑。<Results>受试者被分为2组：HT风险组和HT和HP或HT和SH的高风险组。HT和SH高危组（n=32）与高危组（n = 39）的BOP（p&lt;0.05）和GI（p&lt;0.01）差异有统计学意义。提示本病可能与PHS和CVD有关。牙龈卟啉单胞菌（Porphyromoncis gingivalis，Pg）是牙周病的致病菌，在142例标本中均未检出。而真实的时间PCR法检测的Pg阳性率为90%（9/10）。PCR方法已用于检测不能培养的微生物，但这些方法与相关微生物存在交叉反应，未来应收集更多数据，以阐明该方法与PHS和CVD的相关性，从而准确检测混合菌群中的菌种

项目成果

K.TAMAZAWA, A.OZAWA, Y.TAMAZAWA, H.SHIMAUCHI: "Association Between Periodontal Status and Cardiovascular Risk Factors"Japanese Association for Dental Research (51st Annual Meeting). Special Issue. 119-119 (2003)

K.TAMAZAWA、A.OZAWA、Y.TAMAZAWA、H.SHIMAUCHI：“牙周状况与心血管危险因素之间的关系”日本牙科研究协会（第 51 届年会）。

K.TAMAZAWA, A.OZAWA, Y.YAMAZAWA, H.SHIMAUCHI: "ASSOCHIATION BETWEEN PERIODONTAL STATUS AND CARDIOVASCULAR RISK FACTORS"JOURNAL OF DENTAL RESEARCH. 82:SPECIAL ISSUE C. 435 (2003)

K.TAMAZAWA、A.OZAWA、Y.YAMAZAWA、H.SHIMAUCHI：“牙周状态与心血管风险因素之间的关联”牙科研究杂志。