RELTION BETWEEN PERIODONTAL STATUS AND CARDIOVASCULAR RISK FACTORS

高血压(HT)、高脂血症(HP)和吸烟习惯(SH)是心血管疾病(CVD)的主要危险因素。本研究的目的是调查牙周状况(PHS)与心血管疾病的主要危险因素之间的关系。研究对象为在我校附属医院接受高血压治疗的患者。检查了以下参数。心血管疾病检查：年龄、性别、家族史、病史、吸烟史、生活方式、血压(SBP、DBP、MBP、PP)、脉搏波速度(PWV)、血常规(TCH、高密度脂蛋白、低密度脂蛋白、甘油三酯、尿素氮、尿酸、肌酐、空腹血糖、糖化血红蛋白)、肥胖指数、药物治疗。PHS检查：探诊深度(PD)、探诊出血(BOP)、胃肠道指数、菌斑指数、舌苔评分、呼吸异味。细菌检查：唾液、龈下菌斑。结果：将受试者分为两组：高血压高危组和高血压合并幽门螺杆菌或高血压合并重型肝炎的高危组。高血压合并重型肝炎高危组(n=32)与高危组(n=39)的BOP(p&lt；0.05)和GI(p&lt；0.01)差异有统计学意义。提示其可能与PHS和CVD有关。牙龈卟啉单胞菌(Pg)是一种可能的牙周病原菌，142例标本中均未检出。另一方面，实时荧光定量聚合酶链式反应检测的PG患病率为90%(10份样本中有9份)。目前已有多种方法用于检测不能培养的微生物，但这些方法与相关组织产生了交叉反应。在未来，我们应该收集更多的数据，以澄清该方法与PHS和CVD的相关性，以准确地检测混合细菌种群中的物种

Hypertension (HT), hyperlipidemia (HP) and smoking habit (SH) are major risk factors for cardiovascular disease (CVD). The purpose of this study is to investigate the association between periodontal status (PHS) and major risk factors for CVD. The subjects are patients who undergo treatment for a HT in an affiliated hospital of our university. The following parameters were examined. Examination of CVD : age, gender, family history, medical history, history of smoking, lifestyle, blood pressure (SBP,DBP,MBP,PP), pulse wave velocity (PWV), blood examination (TCH,HDL,LDL,TG,BUN,UA,Cr,FBS,HbA1c), obesity index, medications. Examination of PHS : probing depth (PD), bleeding on probing (BOP), GI, plaque index, coated tongue score, breath odor. Examination of bacteria : saliva, sub-gingival plaque.<Results>The subjects were divided into 2 groups : the risk group with a HT and the high-risk group with a HT and a HP or with a HT and a SH. There were significant differences in BOP (p<0.05) and GI (p<0.01) between high risk group with a HT and a SH (n=32) and the risk group (n=39). This suggested that there may be associated with PHS arid CVD. Porphyromoncis gingivalis (Pg), is putative periodontal pathogens, cannot becultivated in all of 142 samples. On the other hand, Pg prevalence detected by real time PCR was 90 % (9samples out of 10). PCR methods have been used for detection of microorganisms that cannot be cultivated but these methods have given cross-reactions with related organisms.In the future, we should collect more data to clarify correlation to PHS and CVD used by the method to accurately detect species in mixed bacteria populations