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Hand-side difference in human cortical and subcortical systems involved in preparation and movement for lifting an object with a precision grip: PET studies

人类皮层和皮层下系统的手侧差异涉及精确抓握举起物体的准备和运动：PET研究

基本信息

批准号：
13680025
负责人：
KINOSHITA Hiroshi
金额：
$ 1.09万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

Two positron emission tomography (PET) studies were performed in 18 normal volunteers to investigate regional cortical and subcortical activation induced by the lifting-holding- replacing an object repetitively using a precision grip between the index finger and thumb. In lifting of object, t the primary motor (M1), primary sensory (S1), dorso-caudal premotor (PM), caudal supplementary motor (SMA) and cingulate motor cortices contralateral to the hand used were activated. On the ipsilateral side, activation of the M1, caudal SMA, and inferior parietal (BA40) was found. In the subcortical areas, the bilateral cerebellum, left basal ganglla and thalamus were activated. Object weight-dependent activation was observed in the M1/S1 contralateral to the hand used and to some extent in the ipsilateral cerebellum. The areas responsible for preparatory and execution phases for the current lifting task by right and left hands were also investigated. For the prepare and execute condition, the results were similar to the activated areas for lifting action in the first study. BA40 was, however, activated this time in the left side. For the prepare only condition, left SMA and S1 were the activated areas for the right-hand lifting, and for the execute only condition, left M1/S1, PM and thalamus, and right celebellumwere activated. When these tasks were performed by the left hand, there was nearly a mirror image of activated areas seen in the right hand lifting condition. in the preparation task by the left hand, however, the left SMA, right M1 and basal ganglia were activated. Thus, the left SMA is a common area used for preparation of bilateral motor action in these right hand dominant individuals.

在18名正常志愿者中进行了两项正电子发射断层扫描（PET）研究，以研究由食指和拇指之间的精确抓握重复举起-保持-更换物体引起的区域皮质和皮质下激活。在提物动作中，对侧的初级运动皮层（M1）、初级感觉皮层（S1）、背尾侧前运动皮层（PM）、尾侧辅助运动皮层（SMA）和扣带回运动皮层被激活。在同侧，M1、SMA尾侧和下顶叶（BA 40）被激活，在皮质下区，双侧小脑、左侧基底节和丘脑被激活。对象的重量依赖性激活中观察到的M1/S1对侧的手使用，并在一定程度上在同侧小脑。还调查了负责右手和左手当前举起任务的准备和执行阶段的区域。对于准备和执行条件，结果与第一项研究中的提升动作激活区域相似。然而，BA 40这次在左侧被激活。在仅准备条件下，左侧SMA和S1是右手抬起的激活区，在仅执行条件下，左侧M1/S1、PM和丘脑以及右侧小脑被激活。当这些任务由左手完成时，在右手抬起条件下看到的激活区域几乎是镜像。然而，在左手的准备任务中，左侧SMA、右侧M1和基底神经节被激活。因此，左侧SMA是这些右手优势个体中用于准备双侧运动动作的常见区域。