Effects of patho-physiological changes on the toxicokinetics of drug and chemicals.

高酒精偏好（HAP）大鼠和低酒精偏好（LAP）大鼠给药后血浆皮质酮浓度无差异。我们观察到体重增加的显著降低，这是由于反复服用甲基苯丙胺后食物摄入量的减少和血浆皮质酮浓度的升高，即使在短期内也是如此。通过对中毒病例中药物浓度的分析，我们观察到与正常情况下不同的分布模式。我们认为，在大量摄入的情况下，考虑药物在胃肠道中的残留量是进行毒理学评估的重要因素。

There was no difference of plasma corticosterone concentration between HAP(high alcohol preferring) and LAP(low alcohol preferring) rats following ethanol administration. We observed significant lowering of body weight gain, due to the decreased food intake and elevation of plasma corticosterone concentration following repeated methamphetamine administration, even in the short term.We observed the different distribution patterns compare to the regular condition, from the analysis of drug concentrations in poisoning cases. We concluded that it is important to consider the residual amount of the drugs in the gastrointestinal tract for the toxicological evaluation in massive ingestion case.