Development of novel biomaterial using poly(P) and bFGF onto porous hydroxyl apatite

在水平骨再生等骨增强困难的情况下，需要开发能有效促进骨形成的新型仿生材料。我们确定了聚(P)与bFGF结合的最佳链长，我们开发了聚(P)和bFGF与IP-CHA的复合材料，作为可预测的骨再生的创新人工骨。体外研究表明，聚(P)和bFGF通过相互作用促进成骨细胞活性。体内实验也证实poly(P)和b FGF与IP-CHA结合可促进骨形成。

In difficult situation of bone augmentation such as horizontality bone regeneration, development of newly habrized biomaterials with bone formation promoting effective is demanded. we determined the optimum chain length of poly(P) binding to bFGF, we developed a composite of poly(P) and bFGF with IP-CHA as an innovative artificial bone for predictable bone regeneration. that in vitro study, poly(P) and bFGF promote osteoblast activities as interaction efforts. Also in vivo study, poly(P) and b FGF combined onto IP-CHA were established promoted bone formation.