Development of novel biomaterial using poly(P) and bFGF onto porous hydroxyl apatite

使用聚（P）和bFGF在多孔羟基磷灰石上开发新型生物材料

• 批准号: 24792143
• 负责人: HAYASHI Kazuhiko
• 金额: $ 2.75万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24792143/
• 关键词: ｂFGF; 多孔性アパタイト; ポリリン酸; bFGF; 骨増生; インプラント; ハイドロキシアパタイト; ポリリン酸ナトリウム

In difficult situation of bone augmentation such as horizontality bone regeneration, development of newly habrized biomaterials with bone formation promoting effective is demanded. we determined the optimum chain length of poly(P) binding to bFGF, we developed a composite of poly(P) and bFGF with IP-CHA as an innovative artificial bone for predictable bone regeneration. that in vitro study, poly(P) and bFGF promote osteoblast activities as interaction efforts. Also in vivo study, poly(P) and b FGF combined onto IP-CHA were established promoted bone formation.

在水平骨再生等骨增强困难的情况下，需要开发能有效促进骨形成的新型仿生材料。我们确定了聚(P)与bFGF结合的最佳链长，我们开发了聚(P)和bFGF与IP-CHA的复合材料，作为可预测的骨再生的创新人工骨。体外研究表明，聚(P)和bFGF通过相互作用促进成骨细胞活性。体内实验也证实poly(P)和b FGF与IP-CHA结合可促进骨形成。

项目成果

Influence of formalin fixation on implant stability quotient and bone mechanical characteristics

福尔马林固定对种植体稳定性商和骨力学特性的影响

• 发表时间: 2012
• 期刊: Br J Oral Maxillofac Surg
• 作者: Morita K;DOI: K;Oue H;Kajihara S;Hayashi K;Akagawa Y
• 通讯作者: Akagawa Y

Influence of formalin fixation on the implant stability quotient and mechanical characteristics of bone

• DOI: 10.1016/j.bjoms.2012.08.009
• 发表时间: 2013-09-01
• 期刊: BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
• 影响因子: 1.8
• 作者: Morita, Koji;Doi, Kazuya;Akagawa, Yasumasa
• 通讯作者: Akagawa, Yasumasa