Determination of common risk genes associated with periodontitis and autoimmune disease

确定与牙周炎和自身免疫性疾病相关的常见风险基因

• 批准号: 15390644
• 负责人: KOBAYASHI Tetsuo
• 金额: $ 9.28万
• 依托单位: NIIGATA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390644/
• 关键词: Periodontitis; Autoimmune disease; Systemic lupus erythematosus; Rheumatoid arthritis; Common risk gene; Genetic polymorphism; Immunoglobulin Fc receptor; Interleukin 1; 全身性エリテマトーデス; 免疫グロブリン受容体; インターロイキンI; 腫瘍壊死因子受容体; FcγR; FcαR; PCR法; シークエン

To identify common risk genes associated with periodontitis and autoimmune disease, we have evaluated the distributions of the genotypes of the immunoglobulin Fc receptors (FcR) and inflammatory cytokines such as interleukin-1 (IL-1) in patients with both diseases. Our results were as follows :1.A significant association was found between FcγRIIA gene and periodontitis and autoimmune disease, as demonstrated by a case-control study with 213 chronic periodontitis patients, 87 patients with systemic lupus erythematosus (SLE), and 209 controls. These results were supported by a functional study showing a difference in IL-1 production between the FcγRIIA genotypes.2.FcγRIIB nt 775T/C was shown to be a candidate common risk polymorphism associated with both diseases by a case-control study with 58 chronic periodontitis patients, 66 SLE patients, and 44 controls. This FcγRIIB genotype has been suggested to regulate antibody response specific for Porphyromonas gingivalis 40 kDa outer membrane protein.3.IL-1B +3954 was shown as a gene related to onset of rheumatoid arthritis (RA) by an association study with 140 chronic periodontitis patients, 50 aggressive periodontitis patients, 46 RA patients, and 149 controls.

为了确定与牙周炎和自身免疫性疾病相关的共同风险基因，我们评估了免疫球蛋白Fc受体（FcR）和炎症细胞因子（如白细胞介素-1（IL-1））在这两种疾病患者中的基因型分布。结果如下：1.通过对213例慢性牙周炎患者、87例系统性红斑狼疮（SLE）患者和209例对照的病例对照研究，发现FcγRIIA基因与牙周炎和自身免疫性疾病有显著相关性。通过对58例慢性牙周炎患者、66例SLE患者和44例对照的病例对照研究，发现Fc γRIIB nt 775 T/C多态性是两种疾病的共同危险基因型。IL-1B +3954是类风湿关节炎（RA）发病的相关基因，包括140例慢性牙周炎患者、50例侵袭性牙周炎患者、46例RA患者和149例对照。

项目成果

Risk of periodontitis in systemic lupus erythematosus is associated with Fcγ receptor polymorphisms

• DOI: 10.1902/jop.2003.74.3.378
• 发表时间: 2003-03-01
• 期刊: JOURNAL OF PERIODONTOLOGY
• 影响因子: 4.3
• 作者: Kobayashi, T;Ito, S;Yoshie, H
• 通讯作者: Yoshie, H

Interleukin-4 gene polymorphisms in Japanese and Caucasian patients with aggressive periodontitis

• DOI: 10.1111/j.1600-051x.2004.00492.x
• 发表时间: 2004-05-01
• 期刊: JOURNAL OF CLINICAL PERIODONTOLOGY
• 影响因子: 6.7
• 作者: Gonzales, JR;Kobayashi, T;Meyle, J
• 通讯作者: Meyle, J

Fcγ RIIB gene polymorphisms in Japanese periodontitis patients.

日本牙周炎患者 Fcγ RIIB 基因多态性。

• 发表时间: 2003
• 期刊: Gene and Immun 4(8)
• 作者: Yasuda,K.;Yoshie,H.;et al.
• 通讯作者: et al.

The trans-chromosomic mouse-derived human monoclonal antibody promotes phagocytosis of Porphyromonas gingivalis by neutrophil

转染色体鼠源人单克隆抗体促进中性粒细胞吞噬牙龈卟啉单胞菌

• 发表时间: 2005
• 期刊: Journal of Periodontology 76・5
• 作者: Yoshie H;Kobayashi T;Tai H;Galicia JC.;上村参生;Tetsuo Kobayashi;Funashima N.;Kambara M;Akihiro Yoshihara;Funashima N.;Ayano Takauchi
• 通讯作者: Ayano Takauchi

Tetsuo Kobayashi et al.: "Risk of Periodontitis in Systemic Lupus Erythematosus is Associated with Fcγ Receptor Polyimorphisms"Journal of Periodontology. Vol.74, No.3. 378-384 (2003)

Tetsuo Kobayashi 等人：“系统性红斑狼疮的牙周炎风险与 Fcγ 受体多态性相关”，《牙周病学杂志》第 74 卷，第 378-384 期（2003 年）。