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Chemical and genetic diversity of Ligularia species of Yunnan province of China

中国云南省橐吾属物种的化学和遗传多样性

基本信息

批准号：
16404008
负责人：
KURODA Chiaki
金额：
$ 5.82万
依托单位：
Rikkyo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16404008/
关键词：
Ligularia Yunnan Diversity Furanoeremophilane atpB-rbcL ITS International China atpB-rbcL間遺伝子

项目摘要

Field research was carried out in August, 2004-2006, and about 25 Ligularia species were collected as well as hybrid species. It was found that L. cymbulifera and L. duciformis were dominated species in Zhongdian and Litang areas, respectively. For L. tongolensis, L. cymbulifera, L. pleurocaulis, L. virgaurea, and L. tsangchenensis, 10 to 20 samples of each species were collected, and their chemical composition in root and the nucleotide sequences were analyzed. A small diversity was observed for L. tongolensis, while L. cymbulifera was uniform in both chemical composition and the base sequences. Both L. pleurocaulis and L. tsangchanensis could be divided into Yunnan-type and Sichuan-type. Difference in chemical constituents between two types was large in L. tsangchanensis, while two types of L. pleurocaulis were found to be produced related furanoeremophilanes. L. virgaurea in Sichuan province was also divided into two types, but they were not separated geographically. Several new com … More pounds, including virga renones A-D and virgaurenolide A, were isolated and their structures were determined based on spectral data. Analysis of chemical composition and base sequences were also carried out for L. dictyoneura, L. vellerea, L. kanaitzensis, L. latihastata, and L. duciformis, and the presence of intra-specific diversity in each species were clarified. It was found that many different patterns are present in intra-specific diversity. Also, the diversity in chemical composition does not consistent with genetic diversity in some species. Relation between chemical composition and taxonomy was also found. For example, 3,6,15-oxigenated furanoeremophilanes were isolated from Corimbosae species such as L. tongolensis, L. cymbulifera, and L. atroviolacea, while 6,15-oxigenated compounds were obtained from L. vellerea, a Scapicaulis species. Ligularia species producing furano-compounds are though to be ecologically predominant, based on the analysis of L. kanaitzensis, L. dictyoneura, and L. tsangchanensis, and the observation in field. Less

2004年8月至2006年8月进行了野外调查，共采集到橐吾属植物25种及杂交种。结果表明，中甸和理塘地区的优势种分别为cyymbulifera和duciformis。对l . tongolensis l . cymbulifera l . pleurocaulis l . virgaurea和l . tsangchenensis 10到20的样本收集每个物种,及其在根化学成分和核苷酸序列进行了分析。l . tongolensis观察一个小多样性,而l . cymbulifera制服在化学成分和基本序列。胸膜乳酸菌和川芎乳酸菌均可分为云南型和四川型。两种乳酸菌的化学成分差异较大，而两种乳酸菌均产生相关的呋喃嗜氧胺。四川地区的芦笋也分为两类，但在地理上没有明显的区分。在此基础上，分离出了处女烯酮A- d和处女烯内酯A等新化合物，并根据光谱数据确定了它们的结构。此外，还对L. dictyoneura、L. vellerea、L. kanaitzensis、L. latihastata和L. duciformis进行了化学成分和碱基序列分析，明确了各物种的种内多样性。研究发现，种内多样性存在多种不同的模式。此外，在某些物种中，化学成分的多样性与遗传多样性不一致。发现了化学成分与分类的关系。例如，从L. tongolensis、L. cymbulifera和L. atroviolacea等corimboaceae属植物中分离到3,6,15-氧合呋喃菌，而从L. vellerea （Scapicaulis属植物）中分离到6,15-氧合化合物。通过对kanaitzensis、L. dictyoneura和L. tsangchanensis的分析和田间观察，认为产呋喃类化合物的Ligularia属具有生态优势。少

项目成果

期刊论文数量（134）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Total Synthesis and Cytotoxicity of (+)-and (-)-Goniodiol and 6-epi-Goniodiol. Construction of a,β-Unsaturated Lactones by Ring-Closing Metathesis.

(+)-和(-)-Gonidiol 和 6-epi-Gonidiol 的全合成和细胞毒性。通过闭环复分解构建 α,β-不饱和内酯。

DOI：
发表时间：
2007
期刊：
Bull. Chem. Soc. Jpn. 80
影响因子：
0
作者：
K.Nakashima;N.Kikuchi;D.Shirayama;T.Miki;K.Ando;M.Sono;S.Suzuki;M.Kawase;M.Kondo;M.Sato;M.Tori
通讯作者：
M.Tori

Studies of Biological Activity against the Effects Described on the Harb : Biological Active Tests of Chemical Constotuents from Two Brajilian Labiatae Plants.

针对 Harb 所描述影响的生物活性研究：两种巴西唇形科植物化学成分的生物活性测试。