The effects of alcohol and cigarette consumption on blood pressure and the renal function in middle-aged healthy Japanese men

饮酒和吸烟对日本中年健康男性血压和肾功能的影响

• 批准号: 17590559
• 负责人: YAMADA Yuichi
• 金额: $ 2.47万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17590559/
• 关键词: alcohol consumption; smoking; blood pressure; kidney function

The levels of serum creatinine concentration are lower in middle-aged male smokers. Cigarette smoking may significantly affect the circulatory system, causing increases in glomerular filtration rate (GFR) and thus decreases in serum creatinine. A significant linear correlation between the increases in GFR and those in systemic blood pressure (BP) was observed only in smokers, but not in nonsmokers.The increases in GFR in smokers were suggested to be partly related to their increased fasting serum insulin levels. The high GFR and BP were shown to be the major factors related to increased urinary excretion of albumin in middle-aged male population, suggesting that smoking may cause the renal deterioration due to the elevated GFR and BP.

中年男性吸烟者血清肌酐浓度较低。吸烟可能会显著影响循环系统，导致肾小球滤过率（GFR）增加，从而降低血清肌酐。吸烟者GFR升高与体循环血压（BP）升高呈显著线性相关，而非吸烟者GFR升高与空腹血清胰岛素水平升高无相关性。高GFR和高血压是中年男性尿白蛋白排泄量增加的主要因素，提示吸烟可能导致GFR和血压升高，进而导致肾脏功能恶化。

项目成果

Alcohol and cigarette consumption, renal function and blood pressure in middle-aged healthy men

• DOI: 10.1038/sj.jhh.1002242
• 发表时间: 2007-12-01
• 期刊: JOURNAL OF HUMAN HYPERTENSION
• 影响因子: 2.7
• 作者: Noborisaka, Y.;Honda, R.;Yamada, Y.
• 通讯作者: Yamada, Y.