Effects of genetic polymorphisms of alcohol-metabolizing enzymes on the accumulation of acetaldehyde in alcohol consumers from a general Japanese population

酒精代谢酶的基因多态性对日本普通饮酒者体内乙醛积累的影响

• 批准号: 15590562
• 负责人: YAMADA Yuichi
• 金额: $ 2.05万
• 依托单位: KANAZAWA MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590562/
• 关键词: Alcohol consumption; genotype; ALDH2; CYP2E1; acetaldehyde; ADH2

The associations of urinary ethanol and acetaldehyde concentrations with the volume of alcohol consumed and the genotypes of ALDH2 and CYP2E1, and those with alcohol-related health effects, such as BP, serum hepatic enzymes, lipids, UA and glucose elevations, were analyzed in 200 middle-aged Japanese men randomly selected from a working population. Increases in alcohol consumption were significantly related to urinary ethanol concentrations, and urinary ethanol concentrations showed a strong correlation with urinary acetaldehyde concentrations. No significant effects of the genotypes of ALDH2 and CYP2E1 on those associations. Also, no significant effects of urinary acetaldehyde were observed on the alcohol-related health effects.

从工作人群中随机选择200名日本中年男性，分析尿乙醇和乙醛浓度与饮酒量、ALDH2和CYP2E1基因型以及与酒精相关的健康影响（如血压、血清肝酶、血脂、尿酸和葡萄糖升高）的关系。饮酒量的增加与尿乙醇浓度显著相关，尿乙醇浓度与尿乙醛浓度有很强的相关性。ALDH2和CYP2E1基因型对这些关联没有显著影响。此外，未观察到尿乙醛对酒精相关健康影响的显著影响。