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Epidemiological studies on multiple risk factor syndrome in occupational populations

职业人群多危险因素综合征的流行病学研究

基本信息

批准号：
13670391
负责人：
YAMADA Yuichi
金额：
$ 2.37万
依托单位：
KANAZAWA MEDICAL UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

This research is composed of three parts : a literature review on work-related factors affecting weight gain and obesity in occupational populations, testing hypotheses that moderate alcohol consumption could suppress the development of metabolic syndrome and that alcohol-induced hypertension is related to increased insulin resistance and metabolic syndrome. The results are summarized as follows.More than 20% of adult Japanese show a body mass index of 25 or more. Obesity is found more in lower social classes, probably due to dissatisfactions with life and work or unhealthy behaviors. Long work, overtime and shift work are related to weight or waist circumference gain. Heavy work load may result in overeating, sedentary, alcohol and cigarette consumption.In middle-aged men and women, there were no differences in the prevalence of IGT and hypertriglyceridemia between nondrinkers, moderate drinkers and excessive drinkers, showing that moderate alcohol consumption does not suppress the development of metabolic syndrome. However, subjects showing elevated scrum GGT showed a higher odds ratio in hypertension, IGT, hypertriglyceridemia and low HDL-cholesterolemia than those with normal serum GGT. Even moderate alcohol consumption will be a risk of metabolic syndrome in sensitive subjects.In middle-aged healthy men, fasting serum insulin showed a decrease with increases in alcohol consumption, while blood glucose was higher in drinkers consuming 60 ml or more of alcohol, resulting lower values of HOMA-IR and HOMA-BC in alcohol consumers. In alcohol consumers, however, higher HOMA-IR was related higher blood pressure, and moderate elevations in serum GGT were related to a high HOMA-IR and the further elevations were related to a low HOMA-BC. These results suggested that high blood pressure in alcohol consumers is related to changes in serum insulin and glucose relationship, and thus increased insulin resistance.

本研究由三个部分组成：工作相关因素对职业人群体重增加和肥胖的影响的文献综述，适度饮酒可以抑制代谢综合征的发展，以及酒精性高血压与胰岛素抵抗和代谢综合征有关的假设。结果如下：超过20%的日本成年人的体重指数在25以上。肥胖多见于社会下层，可能是由于对生活和工作的不满或不健康的行为。长时间工作、加班和轮班工作与体重或腰围增加有关。在中年男性和女性中，不饮酒者、适度饮酒者和过度饮酒者的IGT和高脂血症患病率无差异，表明适度饮酒并不能抑制代谢综合征的发展。然而，与血清GGT正常的受试者相比，血清GGT升高的受试者在高血压、IGT、高脂血症和低HDL-胆固醇血症中显示出更高的比值比。在中年健康男性中，随着饮酒量的增加，空腹血清胰岛素水平降低，而饮酒60 ml以上的人血糖水平升高，导致HOMA-IR和HOMA-BC值降低。然而，在饮酒者中，较高的HOMA-IR与较高的血压相关，血清GGT中度升高与较高的HOMA-IR相关，进一步升高与较低的HOMA-BC相关。提示饮酒者高血压与血清胰岛素和血糖关系的改变有关，从而增加了胰岛素抵抗。