The effects of continuing and discontinuing smoking on the renalfunction in middle-aged healthy Japanese men and women

继续吸烟和戒烟对日本中年健康男性和女性肾功能的影响

• 批准号: 22590612
• 负责人: YAMADA Yuichi
• 金额: $ 2.91万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590612/
• 关键词: 喫煙; 腎機能障害; 日本人

The aims of the studies are to reveal the effects of smoking on the renal function in Japanese, and to clarify the biological significance of the contradictory high GFR in smokers observed in the previous studies. The associations of smoking with the appearance of proteinuria, the decline of GFR and the development of CKD were observed cross-sectionally and longitudinally in 2,000 workers of a chemical factory and in 7,000 workers who undertook health check-ups. The studies revealed that smoking is a significant factor of the development of CKD, and quitting it reduces the risk. Long observation is required to reveal the fate of high GFR in smokers. Further, serum GGT and blood pressure are remarkably high in smokers having CKD, which may relate to the progression of CDK in smokers.

本研究旨在揭示吸烟对日本人肾功能的影响，并阐明以往研究中观察到的吸烟者GFR高的矛盾的生物学意义。对2000名化工厂工人和7000名接受健康检查的工人进行了横断面和纵向观察，观察了吸烟与蛋白尿、GFR下降和CKD发展的关系。研究表明，吸烟是CKD发展的一个重要因素，戒烟可以降低风险。需要长期观察才能揭示高GFR吸烟者的命运。此外，CKD吸烟者的血清GGT和血压显著升高，这可能与吸烟者CDK的进展有关。

项目成果

Risk factors related to the development of chronic kidney disease (CKD) in middle-aged workers.

与中年工人患慢性肾病（CKD）相关的危险因素。

• 发表时间: 2013
• 作者: Y.Noborisaka,M.Ishizaki,Y.Yamada,R.Honda,H.Yokoyama,M.Miyao,M.Tabata;Y.Noborisaka M.Ishizaki,Y.Yamada,R.Honda,H.Yokoyama,M.Miyao,M.Tabata.;Y.Noborisaka,M.Ishizaki,M.Nakata,Y.Yamada,R.Honda,H.Yokoyama,M.Miyao,M.Tabata.;Yuka Noborisaka;Yuka Noborisaka;Y.Yamada,Y.Noborisaka,M.Ishizaki,R.Honda,H.Yokoyama,M.Tabata,M.Miyao.
• 通讯作者: Y.Yamada,Y.Noborisaka,M.Ishizaki,R.Honda,H.Yokoyama,M.Tabata,M.Miyao.

Distribution of and factors contributing to chronic kidney disease in a middle-aged working population

• DOI: 10.1007/s12199-013-0343-9
• 发表时间: 2013-06
• 期刊: Environmental Health and Preventive Medicine
• 影响因子: 4.7
• 作者: Y. Noborisaka;M. Ishizaki;Yuichi Yamada;R. Honda;H. Yokoyama;M. Miyao;M. Tabata

The effects of continuing and discontinuing smoking on the development of chronic kidney disease (CKD) in the healthy middle-aged working population in Japan

• DOI: 10.1007/s12199-012-0285-7
• 发表时间: 2013-01-01
• 期刊: ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
• 影响因子: 4.7
• 作者: Noborisaka, Yuka;Ishizaki, Masao;Tabata, Masaji
• 通讯作者: Tabata, Masaji

Paradoxical signs of smoking-induced chronic kidney disease (CKD) in generally healthy populations, especially those from workplaces

在一般健康人群中，尤其是来自工作场所的人群中，吸烟诱发慢性肾病 (CKD) 的矛盾症状

• 发表时间: 2011
• 期刊: J Kanazawa Med Univ
• 作者: Y.Noborisaka,M.Ishizaki,Y.Yamada,R.Honda,H.Yokoyama,M.Miyao,M.Tabata;Y.Noborisaka M.Ishizaki,Y.Yamada,R.Honda,H.Yokoyama,M.Miyao,M.Tabata.;Y.Noborisaka,M.Ishizaki,M.Nakata,Y.Yamada,R.Honda,H.Yokoyama,M.Miyao,M.Tabata.;Yuka Noborisaka;Yuka Noborisaka
• 通讯作者: Yuka Noborisaka

Risk factors related to the development of chronic kidney disease (CKD) in middle-aged workers

中年工人患慢性肾脏病（CKD）的相关危险因素

• 作者: 登坂由香;山田裕一;石崎昌夫;本多隆文;田畑正司;宮尾克;末吉秀二;登坂由香;末吉秀二;Yuichi Yamada
• 通讯作者: Yuichi Yamada